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TalkingNutrition

Providing perspectives on recent research into vitamins and nutritionals

Entries filed under 'Nutrigenomics'

    cau-older-woman-eye

    Age-Related Macular Degeneration Risk is Influenced by Vitamin D Status

    Age-related macular degeneration (AMD) is the leading cause of visual impairment and blindness as people age. Two large RCTs (AREDS and AREDS2) have demonstrated that increased consumption of antioxidant nutrients (vitamins C, E, zinc, copper, beta-carotene, lutein, zeaxanthin) can significantly decrease the progression of AMD by ~27%.

    The CARED study measured pigment density (MPOD) of lutein and zeaxanthin in the macula of the retina of 1,803 individuals. 

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    Measuring Folate Status can Trump Genetics

    As a proponent of nutrition status assessments, a common reaction is that personalized insights into our genetics will be the most meaningful information. True but genetic assessments have to be interpreted to be meaningful. For micronutrients, deficiency states are already known. The cutoffs have been established. See the CDC Second Nutrition Report: A Comprehensive Biochemical Assessment of Nutrition Status.

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    baby-mother-hands

    From Newborn Screening to Personalized Nutrition: The Example of Biotinidase Deficiency

    Recently, Vallejo-Torres and co-workers looked at the costs and benefits of introducing biotinidase deficiency screening to the national newborn screening program in Spain. Biotinidase is an enzyme that the body makes to extract the vitamin biotin from food, and also to recycle biotin from its complex with carboxylase enzymes.  When the enzyme does not work as it should, biotin cannot be properly absorbed or recovered after use in the metabolism. How can information about the genetic basis of this disease be used for nutrigenomics?

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    Michael at UN General Assembly

    Vitamin D can be Measured: Has Your 25-hydroxyvitamin D3 been Assayed?

    When it is summertime and beaches beckon, we aren’t very likely to reflect upon vitamin D status. But scientists will. Bhagatwala and colleagues report results from a randomized-controlled trial (RCT) evaluating blood vitamin D responses to vitamin D3 supplementation in overweight/obese African Americans with suboptimal vitamin D status (<50 nmol/L).

    The Institute of Medicine recommended daily intake of 600 IU for adults was insufficient to achieve serum 25(OH)D concentrations of 75 nmol/l in this group whereas 2,000 and 4,000 IU doses daily were adequate.

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    berries

    Benefits of Fruit and Vegetables: Researchers Claim it’s all about Vitamin C

    Rarely does one read a scientific paper with the potential of transforming a field of study. Most research studies ferret out details of a pathway or process. In terms of road construction, research is more often ‘ filling potholes’ to streamline travel than redesigning roads and changing the distance and time required to get from point A to B. Today’s main citation is a landscape change.

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