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Providing perspectives on recent research into vitamins and nutritionals


Vitamin D Supplementation and Health

By Michael McBurney

A colleague of mine, Dr Jane Doe, recently expressed an opinion that vitamin D supplementation is ineffective in raising serum 25(OH)D3 concentrations. Because I respect Jane, her apparent dismissal of the evidence stymied me.

Dear Jane, I hope you saw the paper by Curiel-Lewandrowski and colleagues. High-dose vitamin D supplementation (50,000 IU D3 twice weekly for 8-9 weeks) significantly increased serum 25(OH)D3 concentrations in adults from 21.6 ng/mL (53 nmol/L) to 70.5 ng/mL (177 nmol/L).  There were no adverse effects.

The authors considered serum 25(OH)D3 concentrations < 30 ng/mL (75 nmol/L) as vitamin D insufficient which differs from the Institute of Medicine definition of <20 ng/mL (50 nmol/L). The study goal was to identify biomarkers of vitamin D bioactivity in the skin, including skin with moderate-to-severe sun photodamage. Cytochrome P 450 24 (CYP24) mRNA expression in skin is sensitive to solar exposure and photodamage. CYP24 mRNA responded to vitamin D status and may be a useful biomarker of skin differentiation. My point, Jane, is vitamin D supplementation increases serum 25(OH)D3 concentrations.

Vitamin D3 (cholecalciferol) more effectively increases serum 25-hydroxyvitamin D concentrations than vitamin D2 (ergocalciferol) but let’s be clear; either form will increase vitamin D status. Total 25-hydroxyvitamin D is the sum of metabolites of cholecalciferol and ergocalciferol. Claims that vitamin D2 and D3 are identical are the result of ‘apples and oranges’ comparisons.

Polymorphisms in vitamin D binding protein (VDBP) may partially account for ethnic differences. But do not be deterred. Bischoff-Ferrari and colleagues clearly demonstrate the health benefits of maintaining serum 25(OH)D concentrations above 50, and preferably 75 nmol/L.

Your friend and colleague, Michael

Main Citation

Curiel-Lewandrowski C, Tang JY, Einspahr JG, Bermudez Y, Hsu CH, Rezaee M, Lee Ah, Tangrea J, Parnes HL, Alberts DA, Chow H-HS. Pilot study on the bioactivity of vitamin D in the skin after oral supplementation. 2015 Cancer Prev Res doi: 10.1158/1940-6207.CAPR-14-0280

Other Citations

Heaney RP, Recker RR, Grote J, Horst RL, Armas LAG. Vitamin D3 is more potent than vitamin D2 in humans. 2010 JCEM doi: 10.1210/jc.2010-2230

Carter GD, Phinney KW. Assessing vitamin D status: Time for a rethink? 2013 Clin Chem doi: 10.1373/clinchem.2013.219386

Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, Dawson-Hughes B. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. 2006 Am J Clin Nutr 84:18-28

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whn May 11, 2017 10:57 AM
Under the snow peak, Zhuo is the lake. "Why? So why do this? I just want to be a mother, want to have a child of their own, but you are not willing to pay, every time you are affixed to the fine do not shoot, God, I hate you! I hate you! You are a ruthless selfish person. "A stunning woman stands in the water naked upper body, while crying while patting the lake, chest full of breasts with the body twist Rhythm of the shaking, emitting a white holy luster. The shore of a Qiu must go back and forth pacing, watching a woman in the water sprinkle soared, heart disgust: "You crazy woman, really want the child to be crazy, two people more comfortable, have children do? "Said the air Xiu Xiu turned away, and ignored the woman's crying. "Trained and trained !!" see her husband and ignore their own to leave alone, the woman heartbroken, crying for a while slowly came to the shore. "Call" Suddenly the lake rises in a bucket-like thick snake tail, snake body up to two scales scales glittering, the woman every step of the chest breast and snake around the swing is really good look, line to the lake only to find this stunning woman Turned out to be the first snake body, upper body naked near ten feet, the snake is more than two feet long, on the shore to drive clouds to the east away. Wanshan ancestors, the top of the Kunlun, jade virtual peak of a Tsing Yi old man sigh: "Oh! And quarreled, and nearly nearly eight thousand eight hundred and thirty back! I was this sister is really hard, married the fool Every day to know what Jiugong gossip, stood such a beautiful wife do not accompany the woman is the need to coax you! You do not have time to accompany her, according to her request to give birth to a child to the companion, but not willing to pay A trace of God, really a stubborn and selfish guy, three days to quarrel, has been quarreling for more than a million years, so when the day is a head ah? "Think of this thing between husband and wife is not easy to intervene , Helplessly shook his head and turned to the hole and walked. Line to the way suddenly paused the body, smile soon as: it seems trouble or come to the door, and want to hide can not hide ah! "Brother!" Midwive came a woman's call, come is just in the lake crying people first snake body stunning woman, the old man has always been feeling that the arrival of those who stopped to wait for. Old man slowly turned the body, asked to smile asked: "Shimei today how free to see my old man? Is not and Fuxi quarreled?" Women down the cloud Jiao Jiao said: "Brother, I am not a special trip to To see you, nor to listen to you say that thousands of times all the way, I just come to you to help find a child's way. "" What is the way to find my child! "Old man at the foot of a staggering," Shimei You still bypass my old bones it! If it was Fuxi know that it is not Grilled my skin. "The old man frightened, hand pendulum and rattle like. Woman's face crimson, snapped: "Brother, where do you want to go! Old right! I just come to you to find a child's magic, not to say that you and that ... ..." "What Old man gas beard Alice, Long said: "chaos beginning to this point, I have lived for three million years, and now alone or alone in vain, you! You actually said that I am not serious "The old man angry big sleeves flushed back, the woman was covered with" Puchi "smile. The original, the chaos opened to the beginning of this also five people, they are Hongjun, Pangu, Nu Wa, Pan Xing, Fu Xi, because Hongjun is the birth of the first world of wisdom, behind a few people more or less Have been educated by Hongjun, so everyone is consistent with the Hongjun respect for the big brother. Later Pangu and the plate Xing two fight for the brother of a war, then that war to play the darkness, broken mountains and rivers, sun and the moon without light, the final panic body into a towering Kunlun will be calm in the abyss, can be described as a lose-lose The Now this world also Hongjun, Nu Wa, Fu Xi three, this old man is Hongjun, the first snake body of the woman is of course Nu Wa. So this Hongjun think not single is immune, Nu Wa is laughing for this
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