Bringing microorganisms to production-scale levels is what our business is all about. We achieve it through the ability to choose the right strains – using outstanding technologies like High-Throughput Screening (HTS) and our proprietary PlugBug® platform.
When outsourcing to a CMO you need reliability.
At DSM we have a proven track record of upscaling a wide variety of organisms to scalable and affordable production levels: In fact, we can scale-up batches from 10 to 25,000 liters in a single step.
How do we do achieve this scalability?
This is our game-changing protein platform that enables fast identification of the best strains, scalable to production levels. PlugBug® simply and quickly ‘plugs’ the recombinant DNA encoding for your protein into our ‘bugs’. The result is an elite family of fungi and bacteria known as our PlugBug® - all based on standardized, high cell-density fermentation protocols, with proven performance at production scale – with no intermediate step required, saving you time and money.
This is another key technology that helps us achieve predictable upscaling, with high expression levels and no impurities. HTS has revolutionized microbial science (for proof look no further than the drug Penicillin, where we have improved productivity more than 100-fold using HTS).
Our HTS solution is integrated with the latest robotics technologies and intelligent analytics to help you quickly assess the vast numbers of microbial strains produced by random mutagenesis – and then select those strains with the very best production levels ands purity profiles.
A wealth of experience
Of course technologies are no good without talented and experienced people to use them.
We offer a breadth of expertise in-house to design, develop, improve and upscale the process for manufacturing active ingredients – all of which minimizes time, risk and expenditure in upscaling.