From contact lenses to bioresorbable drug delivery systems, DSM Biomedical provides biomaterials innovation and market insight that turn promising product concepts into viable medical solutions for better eye health. As a pioneer and industry leader in biomedical polymers, customized drug delivery systems, contract R&D and manufacturing services for ophthalmic applications, DSM Biomedical is a trusted partner in new product development.
From initial research and development through clinical testing, regulatory approval and launch, DSM Biomedical has a unique bench-to-market approach that not only allows us to build integrated, long-term relationships with innovative ophthalmic companies but also ensures our understanding of the market, allowing us to anticipate our partners’ needs. Whether your goal is to increase the end-of-day comfort of contact lenses, increase the infection-resistance of eye therapies or develop new pharmaceutical products with superior controlled release characteristics, our combination of scientific expertise and market insight makes us the right partner for successfully navigating the complex and ever-evolving ophthalmic product development environment.
Employing a wide breadth of materials technologies to strengthen the next generation of ocular therapeutics, DSM Biomedical not only turns pipelines into commercial realities, but can complement our partners’ own capabilities by providing services for outsourcing any stage of the product development cycle.
Our diverse portfolio of ophthalmic applications includes:
- Bioresorbable materials providing controlled, sustained delivery of therapeutic compounds locally to the eye, including intra and periocular tissues
- Extensive drug delivery formulations expertise
- R&D and manufacturing of reactive monomer mixes and key ingredients used in state-of-the-art silicone hydrogel contact lenses, including high-purity amphiphilic monomers and oligomers
- Development and manufacturing of advanced biocides used in lens care solutions
- Hydrophilic and antimicrobial coatings for intraocular lens delivery systems/delivery cartridges
At DSM Biomedical we understand how years of research and development can be undone by the wrong approach to manufacturing and commercialization. Our expertise in regulatory compliance, along with our ISO-certified manufacturing operations helps ensure our partners are positioned to successfully manage the growing risks and complexities of product launch and ongoing support within their markets.
Ophthalmic Biomaterials for Contact Lens and Lens Care Solutions
Having a superior understanding of chemical structure property relationships, DSM Biomedical ensures the material needs of its partner translate into superior product performance. Increasing end of day comfort, decreasing infections from new resistant bacterial strains and other performance factors such as increasing lubricity for dry eye patients, are the focus of next generation materials being produced at DSM Biomedical.
DSM Biomedical offers products and manufacturing processes designed to help our partners successfully navigate an evolving industry environment, including:
- Scale-up and manufacturing of contact lens formulations incorporating high-purity amphiphilic monomers and oligomers for state-of-the-art silicone hydrogel lenses
- Polyquaternium and other novel biocides for lens care solutions
- Hydrophilic polyethylene glycol oligomers
- Novel functional silicone monomers, crosslinkers or other high-purity small molecules
- Lubricious, antimicrobial and anti-fouling surface modifications, utilizing Self Assembling Monolayer End Groups SAME® technology
- Surfactants and wetting agents
- Moisture, light and/or heat sensitive materials
To learn more about biomaterials for contact lens and lens care solutions, click here.
Drug Delivery
DSM Biomedical works closely with industry partners to create customized drug delivery systems based on proprietary technologies, offering the following products for advanced ocular drug delivery:
- Injectables, including microparticles, nanoparticles, gels and monoliths (i.e. rods)
- Sustained release profiles (weeks to months)
- Quick release profiles (days to weeks)
- Drug delivery coatings/components for ocular devices
- Specialized systems optimized for delivery of both biologics and small molecules
By applying DSM’s materials science expertise to the most challenging unmet clinical needs in ophthalmology, DSM Biomedical developed the Trancerta™ Drug Delivery portfolio to include the company’s proprietary bioresorbable material platforms as well as an extensive in-house library of synthesis methods, formulation and processing techniques. The material portfolio includes:
- Amino Acid Based Materials which promote interaction between polymer and drug to enhance loading and modulate release. Additionally, the material boasts superior biocompatibility and is enzymatically degradable offering exceptional degradation/release profiles via its inherent surface eroding nature.
- Polythioesters providing novel linking technologies, the thioester chemistry allows fully hydrolysable crosslinks with advanced features built into the building blocks of the more known degradable materials, providing degradation rates of weeks to multiple months.
- Novel Polyurethanes with the ability to control the polymer’s mechanical properties, drug encapsulation, and crosslink density, enabling degradation and drug release to be fully managed and customized.
To learn more about solutions for ocular drug delivery and the TrancertaTM Drug Delivery offering, click here.
Coatings
DSM Biomedical offers hydrophilic and antimicrobial coatings for intraocular lens delivery systems/delivery cartridges.
ComfortCoat® Hydrophilic coating
ComfortCoat® Silverbased Antimicrobial coating
ComfortCoat® Hemocompatbile Antimicrobial coating
VitroStealth™ non-fouling coating
