|
|
|
|
|
|
|
|
Biomedical materials
Bionate® thermoplastic polycarbonate-urethane
Bionate® PCU is an industry-leading medical grade polymer for use in long-term implants and is backed by an established FDA Master File. It has outstanding physical/mechanical properties with proven biostability and biocompatibility. DSM’s surface modifying end group technology allows Bionate® PCU to be provided with customized surface characteristics to address device-specific requirements.
| Benefits | Applications |
- Successfully used in approved medical devices for many years
- Comprehensive FDA Master File with carcinogenicity test results
- Outstanding abrasion resistance when compared to conventional silicone elastomers
- Higher strength than polyether urethanes
- Customizable with SME® technology, utilizing surface modifying end groups
| Neurostimulation, cardiac assist devices, catheters and orthopedic applications including hip and knee joints and prosthetic spinal discs for its outstanding load bearing qualities and biostability. |
Back to top
|
|
|
|
Bionate® II thermoplastic polycarbonate-urethane
Bionate® II PCU is an innovative, medical polymer with built-in surface modification technology. It is designed for chronic implants, with enhanced processing and it is backed by an established FDA Master File. A unique combination of toughness and inherent biostability make aromatic thermoplastic polycarbonate-urethanes candidates for use in chronically implanted devices.
| Benefits | Applications |
- Patented surface modification technology, SAME® technology, utilizing durable self assembling monolayer end groups covalently bonded to the polymer backbone during synthesis
- More consistent surface properties than polymers that contain low molecular weight (wax) processing aides which are susceptible to leaching, and which can cause bonding problems
- Wide range of potential surface characteristics
- Eliminates the need for post fabrication surface modification processes
- Improved oxidative stability
- 10% stronger than first generation Bionate® PCU
- Comprehensive FDA Master File
| Pacemaker leads, ventricular assist devices, catheters, hip/knee joints, dynamic spinal fixation systems, spinal discs and neurostimulation devices. |
Back to top
|
|
|
|
BioSpan® segmented polyurethane
BioSpan® SPU is a medical-grade polymer that offers superior mechanical characteristics, giving devices resistance to flex fatigue. As one of the most elastomeric high-strength biomaterials available, BioSpan® SPU exhibits an impressive combination of properties including excellent flex life, low modulus, high strength and elongation, and proven biostability in many blood contacting applications.
| Benefits | Applications |
- Able to withstand millions of flex cycles in properly-designed devices
- Adaptable for many applications
- Customizable with SME® and SAME® technology, which uses self-assembling, surface modifying end groups
- Comprehensive FDA Master File
| Sac and diaphragm-type ventricular assist devices, artificial hearts, and spinal implants. |
Back to top
|
|
|
|
CarboSil® thermoplastic silicone-polycarbonate-urethane
CarboSil® TSPCU is a ground-breaking copolymer that combines the biocompatibility and biostability of conventional silicone elastomers with the processability and toughness of thermoplastic polycarbonate-urethanes. The silicone soft segment works synergistically with polycarbonate-based polyurethanes to improve in vitro and in vivo stability.
| Benefits | Applications |
- Comparable in strength to traditional polycarbonate urethanes (PCU) and added biostability from the silicone soft segment and end groups
- Adaptable to various fabrication techniques to accommodate many different device shapes
- Improved oxidative stability and thrombo-resistance relative to equivalent polyurethanes without silicone
- Customizable with SME® technology, utilizing surface modifying end groups
- Comprehensive FDA Master File
| Applications where oxidation is a potential mode of degradation, such as in neurovascular and cardiovascular electrostimulation lead insulation and catheters. |
Back to top
|
|
|
|
Elasthane™ thermoplastic polyether-urethane
Elasthane™ TPU is a high-strength, aromatic biomedical polymer with an impressive combination of mechanical properties and biological compatibility.
| Benefits | Applications |
- Designed to support long-term implantation
- Outstanding hydrolytic stability compared to polyester urethanes
- Good thrombo-resistance when used as a smooth blood-contacting surface
- Customizable with SME® technology, utilizing surface modifying end groups
- Comprehensive FDA Master File
| Medical devices and technologies, including pacemaker leads and neurostimulation devices. |
Back to top
|
|
|
|
PurSil® thermoplastic silicone-polyether-urethane
PurSil® TSPU is a novel copolymer that is strong, yet flexible with proven biocompatibility and biostability. Leveraging the benefits of both silicone elastomers and polyether urethanes, PurSil® TSPU has improved in vitro and in vivo stability.
| Benefits | Applications |
- Comparable strength to traditional polyether urethanes (PEU) and added biostability from the silicone co-soft segment and silicone end groups
- Outstanding hydrolytic stability compared to polyester urethanes
- Improved oxidative stability and thrombo-resistance over equivalent polyether urethanes without silicone
- Improved thrombo-resistance when used as a smooth blood-contacting surface
- Customizable with SME® technology, utilizing surface modifying end groups
- Comprehensive FDA Master File
| Medical devices applications, including spinal implants and cardiac rhythm management. |
Back to top
|
|
|
|
Ultra High Molecular Weight Polyethylene (UHMWPE)
UHMWPE has been the material of choice for years in bearing surfaces for total joint arthroplasty. UHMWPE Homopolymer MG003 is the first medical grade for use in implantable devices. A newly developed cross-linkable UHMWPE polymer platform allows for stronger implants with better long-term stability. In addition, a proprietary stabilization technology is available which allows for long-term stabilization without interference during the crosslinking.
| Benefits | Applications |
- Strength
- Excellent wear and fatigue resistance
- High, consistent quality and compliance
- Consistent processability
- High purity
| Orthopedic implants: artificial hips, knees, shoulders, elbows, wrists, ankles and spinal discs
Fibers: a raw material for the ultra strong Dyneema Purity® fibers used in orthopedic sutures and ligament fixation devices. |
Back to top
|
|
|
|
Coatings
ComfortCoat® hydrophilic coating
ComfortCoat® hydrophilic coatings offer favorable handling of catheters during insertion by maintaining lubricity throughout the procedure. They are also designed to enhance maneuverability of metal of various devices, e.g. guidewires, in minimally invasive procedures.
| Benefits | Applications |
- Excellent lubricity
- Superior durability
- Customizable
- Adhesion to many substrates: e.g. Pebax, Nylon, Silicon, Meta
- Proven biocompatibility
| Catheters and guidewires and other devices in vascular, neurological, urinary and ophthalmic applications. |
Back to top
|
|
|
|
ComfortCoat® silverbased antimicrobial coating
ComfortCoat® silverbased antimicrobial coatings can improve the performance of medical devices and reduce the risk of infection. This new technology combines a silver-based, antimicrobial coating with a lubricious hydrophilic coating.
| Benefits | Applications |
- Prolonged anti-microbial effectiveness
- Broad bactericidal and bacteristatic activity
- Less encrustation
- Excellent lubricity and superior durability
- Adhesion to many substrates
- Proven biocompatibility
| Medical devices, including the inner and outer lumen of silicone-based Foley catheters. |
Back to top
|
|
|
|
ComfortCoat® hemocompatible antimicrobial coating
ComfortCoat® hemocompatible antimicrobial coatings offer an innovative coating technology that can improve the performance of medical devices. This coating technology combines hemocompatibility with antimicrobial activity.
| Benefits | Applications |
- Antimicrobial activity
- Hemocompatibility
- Excellent lubricity and superior durability
- Robust and high-throughput UV-cured process
| Target applications for this coating technology are catheters with blood contact and presence in the body up to 30 days, e.g. central venous catheters and intravenous catheters. |
Back to top
|
|
|
|
VitroStealth® non-fouling coating
VitroStealth® is a new non-biofouling technology suitable for a wide range of medical and life sciences devices as it dramatically reduces unwanted protein absorption and cellular adhesion on surfaces. The coating formulations are solvent based and can be applied using a variety of liquid coating techniques.
| Benefits | Applications |
- Easily applied and processed at high speeds
- Excellent non-biofouling properties
- Optically transparent and non-fluorescing
- Fast UV processing
- Crosslinking leads to extremely low levels of extractables and leachables
- Outstanding mechanical durability
- Excellent wetting and capillary flow properties
| Suitable for many applications including blood collection devices, microtiter plates, syringes and diagnostic disposables. |
Back to top
|
|
|
|
Drug Delivery Technology
Trancerta™ Drug Delivery platform
Trancerta™ Drug Delivery encompasses both DSM’s portfolio of proprietary material platforms as well as its extensive in-house library of synthesis methods, formulation and processing techniques. Its innovative products are broadly applicable across therapeutic compounds (small molecules to biologics), bioresorbable, IP protected, designed and optimized for a specific compound or device, and biocompatible and non-inflammatory.
| Benefits | Applications |
- Large portfolio of proprietary materials
- Material science competencies
- Supported by Materials Master Files
| Ophthalmology, (cardio)vascular, orthopedic, and pain management therapeutic areas. |
Back to top
|
|
|
|
|
