Materials that are designed to degrade under physiological conditions are known as bioresorbable materials. These materials are sometimes also referred to as biodegradable, bioerodible, and bioabsorbable polymers. Bioresorbable materials offer advantages in several applications, most notably in drug delivery and next generation medical devices.

Building on the history of known materials…and developing the next generation
Traditional bioresorbable polyesters are derived from five lactone-based safe and biocompatible monomers: glycolide, lactide, e-caprolactone, p-dioxane and trimethlyenecarbonate. The corresponding homopolymers and copolymers are the key ingredients of many commercial medical devices, such as sutures, suture anchors, screws, mesh, adhesion prevention barriers and other implantable devices.

DSM Biomedical offers the next generation of bioresorbable materials to the medical devices and biopharmaceutical industry by employing DSM’s core strengths in material science, an extensive in-house library of synthesis methods and advanced formulation and processing techniques. Equipped with these core competencies, we can tune our materials to meet challenging product design, performance and drug release requisites.

 
For Drug Delivery applications

The Trancerta® portfolio of bioresorbable materials for drug delivery is customized for the controlled release of small molecules and biologics:

• Amino acid based families
• Polyester urethanes
• Polyester amides
• Polyester ureas
• Polythioesters
• Novel polyesterurethanes

All of DSM Biomedical’s portfolio of bioresorbable materials are designed to handle specific drug payloads, to release and degrade based on a requisite profile, and are easily introduced to the target tissue alone or in combination with a device.

These platforms are supported by the strength of full Materials Master Files.

Additionally, by capitalizing on the flexibility in the chemistry and proven biocompatibility of its biostable polyurethane multiblock co-polymers, DSM Biomedical has developed bioresorbable polyurethanes by incorporating degradable linkages into the multiblock co-polymers derived from the glycolic acid, lactic acid, caprolactone, and p-diozanone chemistry.

DSM Biomedical’s portfolio of bioresorbable materials for medical devices is optimized for the unique performance requirements at hand.