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Companion Animals: Folic Acid
Safety

Folic acid has generally been considered a nontoxic vitamin (NRC, 1987). No adverse responses to dietary folic acid have been documented in any species. Acute intravenous toxicity is very low, with the LD50 in mg per kg body weight being: mice, 600; rat, 500; rabbit, 410; guinea pig, 120. In rats, most of the deaths occurred within 30 minutes of injection (Anonymous, 1961). No information is available on folic acid tolerance for dogs and cats.

 
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