Pantothenic acid is generally regarded as nontoxic. No data have been reported for pantothenic acid toxicity studies with dogs or cats. Unna and Greslin (1941) determined an acute LD50 value for calcium pantothenate of about 1 g per kg (0.45 g per lb) of body weight by parenteral injection for the rat but no toxicity at a dose of 10 g per kg (4.5 g per lb) administered orally. Dietary levels of at least 20 g pantothenic acid per kg (9.1 g per lb) can be tolerated by most species (NRC, 1987).