Insufficient data are available to support estimates of the maximum dietary tolerable levels of vitamin B6 for poultry. It is suggested, primarily from dog and rat data, that dietary levels of at least 50 times the nutritional requirements are safe for most species (NRC, 1987).
Large doses of vitamin B6 can produce detrimental effects in experimental animals and humans. Signs of toxicity, which occur most obviously in the peripheral nervous system, include changes in gait and peripheral sensation (Krinke and Fitzgerald, 1988). Changes in central nervous system function were detected in rats fed excessive vitamin B6 using measurement techniques of startle behavior (Schaeffer, 1993).