The RHOBUST® processing platform from DSM is an EBA-based (Expanded Bed Adsorption) chromatographic technique that provides a solution for lab- and pilot-scale recovery of high-value active proteins in a pure concentrated form. EBA represents the most exciting development in the field of separation since the introduction of packed bed chromatography columns back in the 1950s.
A key advantage of the RHOBUST® platform is that it can be used directly with crude feedstock; the chromatographic adsorbent captures protein molecules in one simple downstream process. The EBA process offers a solution that eliminates costly pre-filtration steps, has the potential to deliver significant cost savings for biomolecule manufacture, and opens access to a simple process step for highly concentrated, viscous feedstocks.
These feedstocks include:
- High titer and high density cell culture processes
- Microbial or yeast processes
- Extracts from different sources including challenging plant homogenates
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