Press releases 2008

DSM Biologics, a business unit of DSM Pharmaceutical Products, and Upfront Chromatography A/S, a leading developer of customized industrial-scale separation services, today announced the collaboration between the two companies to optimize Upfront’s new, fully disposable chromatography system for use with DSM's proprietary manufacturing technology.

DSM Biologics, a business unit of DSM Pharmaceutical Products and Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) today announced that German-based MorphoSys AG has decided to extend the PER.C6® technology licensing agreement entered in September 2004, exercising an option for clinical and commercial production of antibodies.

DSM Biologics, a business unit of DSM Pharmaceutical Products and Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) announced today that another important milestone has been achieved with the PER.C6® technology platform for the production of monoclonal antibodies and recombinant proteins.

DSM Pharmaceuticals, Inc. a business unit of DSM Pharmaceutical Products has announced today Mr. Hans Engels has been appointed to the position of President and Business Unit Director of DSM Pharmaceuticals, Inc.

DSM Pharma Chemicals, a business unit of DSM Pharmaceutical Products, has successfully launched PharmaPLE™ during the Informex tradeshow in New Orleans. PharmaPLE™ is a recombinant pig liver esterase, which has been scaled and applied successfully in the synthesis of pharma intermediates

DSM Pharmaceuticals, Inc. a business unit of DSM Pharmaceutical Products and APT Pharmaceuticals, Inc. announced today they have signed a manufacturing agreement.

DSM Pharma Chemicals, a business unit of DSM Pharmaceutical Products and DSM Anti-Infectives are pleased to announce today the DSM team has been awarded the Gold DSM Innovation Award 2007.

DSM recently celebrated being awarded the North Carolina International Community and Economic Development Award, an award given by the N.C. Department of Commerce in recognition of the important civic and philanthropic contributions made by foreign-owned businesses.

DSM Pharmaceuticals Inc. and the Food and Drug Administration (FDA) have recently signed an agreement to collaborate on a project involving Statistical Quality by Design Methodology during Pharmaceutical Manufacturing.