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DSM Biologics and Crucell Announce PER.C6® Licensing Deal With LFB Biotechnologies.
ittard/Leiden,NL,25-Jul-2007

DSM Biologics, a business unit of DSM Pharmaceutical Products and Dutch biotechnology company Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) today announced a non-exclusive PER.C6® research licensing agreement with Paris, France-based LFB Biotechnologies. LFB Biotechnologies will use Crucell’s technology to develop undisclosed antibodies. No financial details were disclosed.

During the research license period, Crucell and LFB Biotechnologies will also evaluate a joint collaboration in the field of enhancing sugar structures, described as glycosylation patterns, on recombinant antibodies using LFB’s in-house developed technology.

About the PER.C6® Technology Platform
Crucell's and DSM’s PER.C6® technology platform has been developed for the large-scale manufacture of biopharmaceutical products including vaccines. Compared to conventional production technologies, the strengths of the PER.C6® technology lie in its excellent safety profile, scalability and productivity under serum-free culture conditions.

About LFB Group
The LFB Group’s mission is to develop, manufacture and market plasma-derived medicinal products and biotherapeutic proteins. Created in 1994, LFB is a public limited company with the French state as a majority shareholder. Based in France, the LFB is the 3rd pharmaceutical group supplying drugs to hospitals in France. LFB SA is a French pharmaceutical company comprised of a holding company and two operating subsidiaries:

- LFB BIOMEDICAMENTS, 1100 employees, produces and markets a wide range of plasma-derived medicinal products.
- LFB BIOTECHNOLOGIES, 200 employees, is dedicated to the group’s biotechnological activities and new medicinal products Research & Development.

LFB S.A. currently has three foreign subsidiaries: LFB Hemoderivados in Brazil, LFB Biopharmaceuticals Ltd in the United Kingdom and LFB GmbH in Germany.

The LFB is ideally placed to become a driving force in new technological and therapeutic fields. LFB focuses its discovery and development activities on monoclonal antibodies and therapeutic proteins for rare and severe diseases mixing and synergising different technologies: plasma purification, cell culture, transgenic production. LFB uses Emabling®, its technology platform, to develop highly functionally optimized antibodies while its R & D portfolio contains high-potential projects calling on innovative technology. For more information about the LFB Group, you can visit http://www.lfb.fr.

About Crucell
Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) is a biotechnology company focused on research, development and worldwide marketing of vaccines and antibodies that prevent and treat infectious diseases. Its vaccines are sold in public and private markets worldwide. Crucell’s core portfolio includes a vaccine against hepatitis B, a fully-liquid vaccine against five important childhood diseases, and a virosome-adjuvanted vaccine against influenza. Crucell also markets travel vaccines, such as the only oral anti-typhoid vaccine, an oral cholera vaccine and the only aluminium-free hepatitis A vaccine on the market. The Company has a broad development pipeline, with several Crucell products based on its unique PER.C6® production technology. The Company licenses this and other technologies to the biopharmaceutical industry. Important partners and licensees include DSM Biologics, Sanofi Aventis, GSK and Merck & Co. Crucell is headquartered in Leiden (the Netherlands), with subsidiaries in Switzerland, Spain, Italy, Sweden, Korea and the US. The Company employs over a 1000 people. For more information, please visit www.crucell.com.

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For more information:
DSM Pharmaceutical Products
Tel. +1 973 257 8471
Terry.Novak@dsm.com
DSM Biologics
Tel.: (+31) 46 47 73343
marcel-m.lubben@dsm.com
LFB SA
Tel: +33 (0)1 69 82 72 80
charrieres@lfb.fr
Crucell N.V.
Tel. +31-(0)71 519 9100
Leonard.Kruimer@crucell.com
Crucell N.V.
Tel: 31-(0) 71 519 7346
barbara.mulder@crucell.com
For Crucell in the US: Redington, Inc.
Tel. +1 212-926-1733
tredington@redingtoninc.com
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