This site uses cookies to store information on your computer. Learn more x

DSM in Medical

Neurology: Advanced neurological repair

According to the World Health Organization, more than 10% of the world’s death and disability is due to neurological disorders. The neurological field has a clinical need for innovations in reinforcement and reapproximation of dural tissue, bridging dural defects, adhesion prevention, and preventing cerebral fluid leakage. Medical device and biopharmaceutical companies are pursuing new and improved tools to help diagnose and treat these disorders. Increasingly, they are turning to the proven biomaterials and capabilities of DSM to help address these needs for advanced neurological repair.
Woman in pliates pose at beach

Neurological disorders and injuries

Electrical stimulation is proving to alleviate painful symptoms and restore function following neurologic disease or injury. Spinal cord stimulators are making strides in restoring neurological functions in the bladder, lungs and limbs. They also are proving effective in treating chronic and intractable pain. Meanwhile, deep brain stimulation is being used for movement disorders such as Parkinson’s disease, tremor and dystonia and is being tested for depression and obsessive-compulsive disorder.

DSM is helping device manufacturers advance the utility of neurostimulators – which isn’t easy. Implanted devices to deliver the energy must be biostable so they won’t break down; and biocompatible so the body doesn’t reject them. Their components must be strong and durable to resist tearing or environmental stress cracking yet thin and flexible to move comfortably with the patient.

Safe, effective implants

Numerous medical devices and technologies have benefited from the combined mechanical properties and biocompatibility of our materials. In fact a hallmark of DSM biomaterials is the ease with which they can be processed into devices.

Medical device companies focused on neurostimulation have used DSM’s proven polyurethanes to develop strong, flexible leads which are less prone to tearing and have demonstrated improved resistance to environmental stress cracking. Our polymers can be customized to different degrees of hardness to meet specific device design needs. Our extensive experience in surface chemistry employing our patented Surface Modifying End Group (SME®) technology can alter the surface of a device for specific applications. DSM has a proven record of success with lead insulation in neurostimulators where electrical insulation properties are critical for device effectiveness – and patient safety.

As device manufacturers look to make smaller devices to improve patient comfort via less invasive procedures, they are incorporating our Dyneema Purity® fiber into their device designs as it allows reinforcement of devices with smaller diameters, yet with similar mechanical strength. Our Dyneema Purity® fiber is being evaluated for use in reinforcing neurocatheters to help preserve the mechanical integrity of the neurostimulation lead.

Bioresorbable medical devices

DSM works across three technology platforms to design, develop and manufacture bioresorbable medical devices that address the complex requirements for neurologic surgery. Our collagen, Extracellular Matrix (ECM) and synthetic polymer technologies allow tailored design of scaffold materials. These provide structural support for tissue regeneration while they are remodeled by host tissue and resorbed by the body.

We have expertise in formulating devices by utilizing our proprietary Porous Tissue Matrix™ material, naturally-derived collagen constructs and Extracellular Matrix (ECM) technology to create innovative solutions for dural repair. Additionally, we have extensive knowledge and ability to produce a wide range of neurological devices, such as cranial plates and resorbable fixation screws.

Drug delivery

In the growing area of drug delivery, our polyesteramide (PEA) technology was developed to help relieve pain by delivering powerful analgesics directly to the site of the pain. For example, we are now working with biopharmaceutical industry engineers to assure precise medication delivery to the spine.

Drug delivery

Neurostimulation

  • Brain/spinal cord injuries
  • Movement disorders
  • Pain management

Neurosurgery

  • Cranial plates
  • Resorbable fixation screws
  • Scaffolds

Biomedical polyethylenes

Collagen materials and technology - More>

  • Purified collagen
  • Solution and slurry processing
  • Collagen blending and compounding
  • Multiple configurations (sheets, putties, injectables, gels, three dimensional shapes, coatings, fibers, and powders)

Polymers and metals processing technology - More>

  • Resorbable materials [Polylactide (PLA), Polylactide-co-glycolide (PLGA), Polycaprolactone (PCL), Polycarbonate (e.g. TMC)]
  • Non resorbable materials (PEEK, TPU)
  • Implant-grade metals ( titanium, stainless steel)