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DSM in Medical

Adhesive technology

Medical adhesive biomaterial in protective coatings and adhesive films

DSM adhesive technology was inspired by marine mussels and the remarkable substance they secrete to bond to underwater surfaces. Our scientists create synthetic mimetics of these proteins and use them to build adhesive polymers that can be tailored to fit a broad variety of indications.

Recognized adhesive technologies

Our innovations were recognized with a title article in the July 2007 issue of Nature and they were labeled "one of the top 100 scientific developments of 2007" by Discover Magazine.  Our collaborators have won numerous awards for research using marine mussel adhesive technologies.

Nature magazine cover

Medical indications & partnership opportunities

DSM offers adhesives that may be applicable across a broad variety of medical indications; as standalone products or as adjuncts to other medical devices.  We engage corporate partners to develop products that meet the medical needs of many different surgical procedures.

The flexibility of our chemistry enables us to tailor performance characteristics of the material specifically for each application.

Delivery system for surgical adhesives

Our products are typically delivered as a hydrogel in situ or pre-coated onto an adjunctive medical device. The delivery system can also be tailored to the application for ease of surgical use and optimal distribution of the medical adhesive.

DSM polymers are “tuned” to meet our partners’ requirements. We can vary:

  • Set (cure) time
  • Degradation time
  • Swelling volume
  • Elasticity
  • Other characteristics

All of these can be changed without significantly impacting our superior burst, peel, and shear strength.

Protective antifouling coatings

Bacterial infections complicate the outcome of millions of medical procedures each year.  Catheters, orthopedic implants, and other devices can become the locus of infection when pathogenic bacteria form biofilms. DSM is developing anti-fouling coatings to prevent bacteria from attaching to surfaces, thereby disrupting the formation of biofilms and their harmful consequences.

Antifouling surfaces for medical devices

DSM couples a biocompatible surface anchoring group to an antifouling polymer, such as polyethylene glycol (PEG), to passively inhibit bacteria from adhering to the medical device.  Because bacteria cannot colonize on the device surface, they cannot create biofilms.

Benefits of antifouling coatings

Many medical device coatings attempt to reduce bacterial infection by releasing active biocides.  These biocides may not protect against new bacterial strains, and may actually promote the evolution of resistant strains.  Moreover, the biocides can prove toxic to surrounding tissues.

DSM is designing anti-fouling coatings aimed at preventing bacterial attachment and colonization on a device surface by any bacterial strain. Importantly, anti-fouling coatings may also reach the market with lower regulatory costs because they do not contain active biocides.

Performance of DSM antifouling coatings

In preliminary testing, the DSM anti-fouling coatings have reduced bacterial attachment by more than 99% over untreated titanium surfaces.