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DSM in Medical

Cartilage Repair Device Technology – European Union

Today's techniques for treating chondral or osteochondral defects commonly include microfracture and transplantation procedures. These techniques typically provide temporary relief, however, concerns remain about limited graft availability, morbidity at the autograft donor site, graft hypertrophy, the need for multiple surgical interventions and excessive cost. These current techniques, though beneficial in temporarily reducing pain, cannot be considered long-term solutions.

Biphasic Design

DSM has developed technologies to address these deficiencies. The Cartilage Repair Device (CRD) is a unique synthetic bioresorbable implant designed to address chondral and osteochondral defects. CRD technology utilizes a biphasic design containing two discrete layers, each specifically engineered to favor the growth of the histologically distinct tissues of articular cartilage and subchondral bone.

The chondral phase consists of a unique Type I collagen matrix that provides a malleable, flexible substratum that allows cell infiltration and de novo formation of hyaline tissue. The subchondral phase consists of β -TCP (tricalcium phosphate) mineral suspended within a porous bioresorbable synthetic polymer scaffold. This matrix provides an appropriate mechanical and chemical environment to facilitate the influx of cells and remodeling into normal bony architecture, an important component in a successful cartilage regeneration effort.