Cartilage Repair Device Technology – European Union
DSM has developed technologies to address these deficiencies. The Cartilage Repair Device (CRD) is a unique synthetic bioresorbable implant designed to address chondral and osteochondral defects. CRD technology utilizes a biphasic design containing two discrete layers, each specifically engineered to favor the growth of the histologically distinct tissues of articular cartilage and subchondral bone.
The chondral phase consists of a unique Type I collagen matrix that provides a malleable, flexible substratum that allows cell infiltration and de novo formation of hyaline tissue. The subchondral phase consists of β -TCP (tricalcium phosphate) mineral suspended within a porous bioresorbable synthetic polymer scaffold. This matrix provides an appropriate mechanical and chemical environment to facilitate the influx of cells and remodeling into normal bony architecture, an important component in a successful cartilage regeneration effort.