47th Annual ESDR Meeting
- 27 Sep 2017
- End Date:
- 30 Sep 2017
- Salzburg, Austria
- In attendance:
Connect with Dr. Remo Campiche, Scientist at DSM during the poster sessions of September 28-30 at the poster number 652 with the title: Protection strategies to inhibit blue light irradiation effects in-vitro and in skin ex-vivo.
What can you expect from the poster session?
The negative impacts of visible light, particularly high energy visible light (HEV) or blue light (wavelength 380-500nM), to skin are still not fully understood. A few studies have shown an increase of blue light-induced oxidative stress and hyperpigmentation in-vitro suggesting a contribution to photo-aging. Only two UV-filters were found to partially block wavelength >400nm, hence additional means of protection are needed. We investigated blue light-induced cutaneous damages and screened for compounds to suppress these damages. Vitamins B3, B6 and E could prevent beta-carotene from blue light-dependent degradation in-vitro on PMMA plates. To investigate the potential of these compounds to suppress blue light induced damages in skin, we developed an ex-vivo model of blue light irradiation. Using fluencies of up to 100J/cm2 we could show a dose-dependent increase of reactive oxygen species, and we established protein carbonylation as a novel marker of blue light induced skin damage. We found that distinct compounds like vitamin B3 as well as an extract of the freshwater microalga Scenedesmus rubescens could suppress blue light induced damage significantly (p<0.05). In summary, we provide evidence that blue light induces cutaneous damage via protein carbonylation, that can be suppressed by specific vitamins or algae extracts.
The major goal of the ESDR is to enable the future of skin science through scientific exchange and education. The annual scientific meeting of the ESDR has a central role in this endeavor by providing a world leading platform for the presentation and discussion of state of the art science as it relates to skin biology. The program includes named orations from outstanding globally recognized scientists, plenary educational events such as Frontiers in Skin Biology and Dermatology, workshops, symposia and free communications covering all aspects of skin science extending from genetic discovery through to clinical research. In all this, the ESDR aims to disseminate information about cutting edge technology and new approaches to scientific discovery. ESDR is committed to fostering a culture where scientists and clinicians can get together, exchange ideas and form new collaborations in a convivial and stimulating environment.