Hyaluronan (HA)is a so called glucosaminoglycan (GAG) that consists of a long sugar chain that can bind up to 1,000 times its weight in water. The excellent moisture-holding property (see DSM’s Hyaluronic Acid BT for topical use) leads to a gel-like framework for collagen, elastin and skin cells. Also important is its ability to act as a filler, which helps provide the skin with mechanical cushioning. Decorin and lumican are two important proteoglycans of the dermis. Their protein part binds to a collagen fibril while the GAG part acts as a spacer between the fibrils (see figure opposite). The result is the formation of thinner collagen fibrils with increased quality and strength. Both activities of SYN®-HYCAN work nicely together: Fresh hyaluronan and stronger collagen fibrils result in a visible remodeling effect and a firmer skin.