Biosecurity needs a strong immune system to fend against pathogens; it is true for laying hens and egg consumers

Biosecurity is a major consideration for egg farmers across the world, and can be regarded as the ecosystem of measures capable of preventing the spread of harmful organisms to animals to reduce the risk of transmission of infectious diseases. Strong biosecurity requires all preventative measures to work collaboratively, from vaccines to physical barriers, hygiene practices, personal protective equipment (PPE) and bio-monitoring. It is essential that all elements are working in sync, with no weak links, to maximize production and minimize casualties.

An important link to biosecurity and the spread of virus, which can sometimes be forgotten, is the performance of the immune system. It is the first barrier of defense against pathogens, both bacterial and viral origin. A good layer immune system will ensure the animal has a strong response to vaccines and will help to reduce the severity of infections. In a recent paper (1) the importance of nutritional status on the process of protecting against viral infections was highlighted.

Vitamins A, B6, B12, C, D, E and folate; trace elements like zinc, iron, selenium, magnesium and copper and Omega 3 fatty acids, are all important in supporting an optimal functioning of the hen’s immune system. For instance, vitamin A is known to increase protection against Newcastle disease by increasing the body titer. While vitamin D is known to protect hens from immunological stress (3), it also reduces the susceptibility of egg yolk oxidation, thus improving the storage time of eggs. In addition, vitamin E has a modulatory effect on the immune system via the activation of macrophages and production of antibodies, necessary for the prevention and resistance against various diseases (4). As a bonus to strengthening the immune system, providing optimal nutrition also enables the hen to be less prone to bone deformities (osteoporosis) and helps to enhance the egg shell quality.

Providing optimum nutrition to laying hens is essential not only in boosting and maintaining the immunity of the layer, but also in protecting nutritional value of the eggs for consumers. Eggs are considered to be one of “nature’s first foods” with evidence mounting about the benefits of eggs for child nutrition and potential benefits for women during pregnancy and birth outcomes (5). The unique egg matrix of macronutrients, micronutrients, and immune factors, means eggs contain the majority of the essential nutrients required by the body, promoting growth, and potentially also helping child development (5). As is explained by Lutter et al., in their paper on the ‘potential of a simple egg to improve maternal and child nutrition’.

It is also possible to bolster the already impressive nutritional value of the egg, by enhancing with DHA, Omega 3, Vitamin E, D and folate. In addition, eggs may also provide the human body with nutrients and other immune factors in compounds that are more readily absorbed and metabolized, in comparison to single nutrient supplements (5). These are all important elements in the process of boosting the immune system of the consumer, but also the laying hen.

As an example, The triple benefit of vitamin D metabolite is illustrated in Figure 1 UN(Link) DSM business drivers link.

Figure 1. The triple role of 25OHD3 (Hy-D®) on layer hen nutrition and sustainability of the egg industry.

Dietary supplementation of 25(OH)D3 is known to lift layer hen vitamin D status and subsequently optimise calcium and phosphorus metabolism, help modulate the immune response in layers , and increase the vitamin D content in eggs. These three actions put together will exert a beneficial effect on reducing egg production environmental foot print and increase sustainability and profitability via the reduction in the amount of broken eggs. The welfare of the layer is equally improved by an improvement on the skeletal health. Another study published in 2020 (2) highlights the fact that the Vitamin D metabolite “25(OH)D3 suppresses the production of inflammatory cytokines and reduces virus replication and clinical manifestations of influenza virus infections in a mouse model”. This Vitamin D metabolite can be supplemented in the diet of the hen, to increase the Vitamin D activity of the egg by up to five times.

In conclusion, when we provide laying hens with a diet rich in vitamins, minerals and trace elements, we are supporting the biosecurity process of the whole flock, while at the same time enhancing the nutritional status of the human population consuming eggs and egg product, a win-win situation for the egg producer and the consumer.


(1)   Calder, P.C. et al., 2020. Optimal Nutritional status for a well-functioning immune system is an important factor to protect against viral infections. Nutrients. Doi: 10:3390/nu12072000

(2)   Hayashi, H., et al. 2020. Oral supplementation of the Vitamin D metabolite 25 (OH) D3 against influenza virus infection in mice. Nutrients. Doi: 10:3390/nu12072000

(3)   Geng, Y. et al., 2018. Nutrition and Metabolism 15:58. Dietary vitamin D 3 supplementation protects laying hens against lipopolysaccharide-induced immunological stress. DOI: 10.1186/s12986-018-0293-8

(4)   Zang, H. et al., 2011. Effects of different dietary vitamin combinations on the egg quality and vitamin deposition in the whole egg of laying hens. Br. J. of Poultry Sci. 13:113.  

(5)   Lutter, C. K., Iannotti, L. L., & Stewart, C. P. (2018). The potential of a simple egg to improve maternal and child nutrition. Maternal & Child Nutrition, 14(Suppl 3), e12678.

Published on

19 January 2021


Murtala Umar Faruk

Kalpana Beesabathuni

About the authors

Murtala Umar Faruk

Kalpana Beesabathuni


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