As summer fades and fall approaches in the northern hemisphere, the cycle of life comes to mind. What will senescence bring? Cognitive decline is evident in 45-49 year olds and it continues with aging (Singh-Manoux et al, 2012). Can better nutrition change the outcome?
Haptoglobin is an antioxidant protein which helps prevent hemoglobin-induced oxidative damage. Genetic polymorphisms in the haptoglobin protein are known to interact with vitamin E status, partially explaining a 3-5 fold effect on cardiovascular disease risk in some individuals with diabetes (Vardi et al, 2012). In a new study, Ravona-Springer and colleagues report a similar interaction between haptoglobin genotype and cognitive functioning in elderly individuals with diabetes.