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Providing perspectives on recent research into vitamins and nutritionals


Multivitamin-Mineral Supplements, Insuring Nutritional Status and Mood

By Michael McBurney

Inadequate vitamin and mineral intake can lead to suboptimal vitamin and mineral concentrations that affect metabolic processes in the brain, and therefore mood. In a meta-analysis of 8 RCTs, Long and Benton reported a beneficial effect of multivitamin-mineral supplementation. In particular, high doses of B vitamins may be affective. In 2013, Davison and Kaplan wrote “Nutrient intakes warrant further consideration in the treatment of people with mood disorders.

In a new study, White and colleagues report on the effect of 4 week trial in 58 healthy, young adults with a multivitamin-mineral supplement. Individuals with psychiatric or medical histories were excluded from the randomized controlled trial (RCT). The multivitamin-mineral product contained B vitamins (thiamin, niacin, niacin, B5, B6, B12, folic acid, biotin), vitamin C, calcium, magnesium and zinc. Supplementation significantly increased blood concentrations of vitamin B6, folate, and B12 and decreased homocysteine concentrations. Significant differences were observed in depression/dejection scores.

Lower blood vitamin B12 concentrations has been previously associated with increased risk of depression in community-dwelling older women. Vitamin B12 deficiency is associated with a 2-fold greater risk of severe depression. Multivitamin-mineral supplementation has mood benefits among males.

Multivitamin-mineral supplements with B vitamins are a safe, effective means to improve nutrient intake/status and decrease homocysteine concentrations . Supplementation enhances treatment response to antidepressants.

A daily multivitamin-mineral supplement is a smart strategy, helping insure nutritional requirements are met and cells throughout the body, including the brain, get needed support.

Main Citation

White DJ, Cox KHM, Peters R, Pipingas A, Scholey AB. Effects of four-week supplementation with a multivitamin/mineral preparation on mood and blood biomarkers in young adults: A randomized, double-blind trial. 2015 Nutr doi: 10.3390/nu7115451

Other Citations

Davison KM, Kaplan BJ. Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders. 2013 Can J Psych 57(2):85-92

Long SJ, Benton D. Effects of vitamin and mineral supplementation on stress, mild psychiatric symptoms, and mood in nonclinical samples: A meta-analysis. 2013 Psychosom  Med doi: 10.1097/PSY.0b013e31827d4fbd

Penninx BWJH, Guralnik JM, Ferrucci L, Fried LP, Allen RH, Stabler SP. Vitamin B12 deficiency and depression in physically disabled older women: Epidemiologic evidence from the Women’s Health and Aging Study. 2000 Am J Psych 157(5):715-721

Kennedy DO, Veasey RC, Watson AW, Dodd FL, Jones EK, Tiplady B, Haskell CF. Vitamins and psychological functioning: a mobile phone assessment of the effects of a B vitamin complex, vitamin C and minerals on cognitive performance and subjective mood and energy. 2011 Human Psychopharm doi: 10.1002/hup.1216

Almeida OP, Ford AH, Hirani V, Singh V, van Bockxmeer FM, McCaul K, Flicker L. B vitamins to enhance treatment response to antidepressants in middle-aged and older adults: results from the B-VITAGE randomized, double-blind, placebo-controlled trial. Br J Psych doi: 10.1129/bjp.bp.114.145177