Numerous clinical studies, meta-analyses and systemic reviews have established that oat beta-glucan lowers plasma low-density-lipoprotein-cholesterol (LDL-C) levels. A meta-analysis by Whitehead et al. 2014 (1) showed that oat beta-glucan at doses of 3 g per day significantly decreases both total cholesterol and LDL-C levels. The outcomes suggest that high viscosity oat beta-glucan can reduce cholesterol, while low viscosity products have no significant effect. The physicochemical properties of beta-glucan - notably its molecular weight (MW) and viscosity - are key to the physiological benefits observed with beta-glucan products. The degree of polymerization of the beta-glucan is directly reflected in the viscosity, and the viscosity depends on the molecular weight.