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DSM in Food, Beverages & Dietary Supplements

Tolerase® L 

Tolerase® L is an acid lactase that converts lactose into glucose and galactose. It is developed for use in dietary supplements for lactose intolerant people, giving them the freedom to enjoy dairy products.
Tolerase L logo

Tolerase® L is an acid lactase that converts lactose into glucose and galactose. The enzyme originates from a special strain of the fungus Aspergillus oryzae. Its activity at low pH (3.5 – 5.5) makes this lactase particularly effective to digest lactose in the stomach and is therefore ideal for use in dietary supplements as a digestive aid.

Lactose is a milk sugar, naturally present in dairy products. It is digested by the enzyme lactase into glucose and galactose, which are absorbed into the bloodstream. Lactose-intolerant people lack this enzyme and as a result are unable to digest lactose fully.

If undigested, lactose reaches the large intestine where it is degraded by its microflora. The resulting by-products may cause symptoms of lactose intolerance including diarrhea, abdominal cramps, flatulence and nausea. When lactose-intolerant people stop consuming dairy products, their intake of calcium tends to be lower, which can put their bone health at risk.

Woman drinking Milk and enyoing it

About 50% of the world’s population is lactose intolerant, meaning that they cannot drink milk or consume dairy products without experiencing these uncomfortable symptoms. The prevalence of lactose intolerance varies across the world. In general, people from western countries are less prone to lactase deficiency, but still up to 20% of the population is unable to digest lactose. In Latin America, Africa and Asia the prevalence of lactose intolerance is much higher. For instance, in China almost all the population is lactose intolerant.

Key benefits of Tolerase® L

  • A highly efficacious and safe enzyme with a positive opinion from EFSA: ‘Contributes to breaking down lactose
  • Feel the benefit: helps to eliminate discomforts associated with lactose intolerance such as abdominal pain and cramps, bloating, flatulence, and diarrhoea
  • Regulatory compliance in key markets
  • Low cost in use
  • Consistently high activity level (100,000 ALU/g), allowing small tablet size
  • Excellent tabletting properties: white colour, superior flowability, suitable for direct compression, neutral taste
  • Strong scientific substantiation for acid lactase
  • Manufactured by DSM, global leader in food enzymes


The dose of Tolerase® L is dependent of the amount of lactose and the size of the meal consumed. In general, a larger meal remains in the stomach for longer and therefore less enzyme is required then when the same amount of lactose is consumed with a light meal or just a glass of milk. A general guideline is 2,500 ALU per 10 – 13 grams of lactose consumed. The European Food Safety Authority recommends a dose of 4,500 ALU with each lactose-containing meal. For very sensitive lactose-intolerant consumers (needing a 100% conversion) 10,000 ALU per meal is recommended. Over time, consumers will quickly establish an effective dose.

How it works

Tolerase T: Graphs showing the H2 breath test