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DSM in Medical

Technical data

The Meso BioMatrix® Surgical Mesh is a porcine mesothelial extracellular matrix (ECM) product developed for soft tissue repair applications that require enhanced drape and conformability. It is made from our proprietary OPTRIX™ process, which gently disinfects tissues, inactivates viruses and removes cells while preserving extracellular matrix components.

Preservation of native structure

  • Excellent strength and durability without crosslinking
  • Porous, open structure provides scaffold for cell infiltration
  • Preservation of basal lamina 1

Retention of bioactive components

  • Guided regeneration
  • Facilitates rapid cell infiltration and revascularization

Designed with the surgeon in mind

  • Hydrates in <5 minutes
  • Desirable handling characteristics: soft, supple and conformable

Proven In-Vitro* biologic activity

DSM invests in comprehensive analysis of our extracellular matrices to validate the gentle selectivity of the OPTRIX™ process. In vitro results demonstrate the potential for increased biologic activity:

  • More rapid cell infiltration compared to dermis xenograft products2
  • Greater retention of TGF-B and VEGF relative to incumbent commercial products2

Potential Clinical Applications

At DSM we know that every clinical need poses unique challenges and requires specialized tools. The versatility of our OPTRIX™ processing methods provides the opportunity to address a variety of soft tissue repair needs, such as:

  • Abdominal wall reconstruction
  • Suture/staple line reinforcement
  • Plastic and reconstructive surgery
  • Pelvic floor reconstruction
  • Dura substitute
  • Rotator cuff repair
  • Nerve conduit

References

  1. DSM, Data on File
  2. BioMaterials. 2010 Sep;31(27):6934-40.

Regulatory approvals are necessary before the use of Meso BioMatrix® Surgical Mesh in human applications.

In vitro results are not necessarily indicative of clinical performance.