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DSM in Personal Care

IFSCC Congress 2018 Munich

DSM Personal Care was one of the main sponsors at this year’s scientific congress IFSCC 2018, held from September 18-21 in Munich. Our scientists want to thank all of you who passed by at our booth or connected with us during the event.
ifscc-congress-2018-munich-rte

Left to right: Dominik Imfeld, Remo Campiche, Thomas Rudolph, Mathias Gempeler, Carmina Casas, Rolf Schütz, Eileen Jackson, Jürgen Vollhardt, Rainer Voegeli, Andrea Grosz

In case you missed us at the congress, please find all the 10 presented posters for download here.

Poster number: P-S4-011
Title: Phenotypic changes in the corneome and ceramidome of photodamaged dry facial stratum corneum from different ethnic groups
The aim of this study was to utilise mass spectrometry-based ceramidomics and proteomics to understand more precisely the effects of stratum corneum maturation and its relation to facial photodamage, skin pigmentation and ethnicity and to explain some of these differences.
The study was a co-operation between DSM, Phylogene (FR), Lipotype (DE), Sefako Makgatho Health Sciences University (ZA) and AVR Consulting (UK)

Poster number: P-S4-012
Title: Changes in protein deglycase DJ-1 expression with age in photoprotected and photoexposed skin
Protein deglycase DJ-1 is an anti-oxidant protein. It recently has been found, in the stratum corneum, to be associated with the skin’s response to ultraviolet radiation. We therefore dedicated this research to learn more about this potentially important protein for skin health and its changes with age.
The study was a co-operation between DSM, the University of Manchester (UK) and AVR Consulting (UK)

Poster number: P-S4-038
Title: Characterization of the lipids from the corneocyte lipid envelope of human stratum corneum
The objective of this study was the investigation, quantification, and comparison of the molecular composition of the lipids of the corneocyte lipid envelope and the characterization of covalently bound ceramides.
The study was a co-operation between DSM, Martin-Luther-Universität Halle-Wittenberg (DE), Sefako Makgatho Health Sciences University (ZA) and AVR Consulting (UK)

Poster number: P-S4-095
Title: Image-based continuous p-value evaluation: A novel approach to detect and visualize integral efficacy of skin care treatments
Based on the recently introduced color mapping technology, we now present a novel approach to continuously map statistical significance levels (p-values) of cutaneous parameters on the face. We relate this approach to skin tone modulation on Asian volunteers using an anti-aging peptide.
Authors: Remo Campiche, Sarah Gougeon, Rainer Voegeli, Marie Cherel, Anthony V. Rawlings and Pierre Séroul

Poster number: P-S4-113
Title: The effect of relative humidity on ex -vivo maturation of facial corneocyte envelopes in Chinese subjects
The aim of this work was to screen the maturity of corneocyte envelopes at different relative humidity’s and to determine transglutaminase activity on tape stripping’s obtained from photo-exposed and photo-protected facial sites of Chinese.
The study was a co-operation between DSM, the University College of London (UK) and AVR Consulting (UK)

Poster number: P-S4-355         
Title: Deciphering the action of (R)-10-hydroxystearic acid, on the secretome of dermal fibroblasts by mass spectrometry-based proteomics 10-hydroxystearic acid has shown to improve in- vivo on human skin the appearance of age spots and conspicuous pores. In this study we are using proteome analysis to get the full picture, of which protein-based biological markers are up- or downregulated to give more insights and understanding on the biochemical mechanisms that are potentially involved
Authors: Dominik Imfeld, Eliane Wandeler, Rolf Schuetz, Gilbert Skorski and Anthony Rawlings

Poster number: P-S1-501         
Title: Inhibition of cutaneous cortisol activation: a novel approach to protect skin from stress induced damage and accelerated aging
With hectic lifestyle induced stress and age the cortisol level in skin increases and causes negative effects on skin. We show the story of our innovation BEL-EVEN® and for the first time the scientific publication of the in-vivo study results demonstrating the impressive benefits from cortisol inhibition which is a huge need for today’s consumer.
Authors: Dominik Imfeld, Remo Campiche, Eliane Wandeler and Eileen Jackson

Poster number: P-S2-326
Title: How to establish a meaningful blue light protection claim?
The damaging effect of solar UV irradiation on skin is well documented, whereas the contribution of the visible light, especially the high energetic blue light is not fully understood. Here, we report methods for scientific claim substantiation on blue light protection that relate to consumer relevant situations. The proposed workflow facilitates a viable way for claim substantiation resulting in suitable ingredients that combine antioxidant supplementation and blue light filters for bio-physical protection of skin against visible light, especially related to outdoor and indoor and exposure to blue light.
Authors: Rolf Schuetz, Christine Mendrok-Edinger, Remo Campiche, Karolina Strauss, Jürgen Vollhardt

Poster number: P-S2-328
Title: Consumers using less than recommended to optimize the appeal of sunscreens – A consumer habits and practices study compared to the sensorial reality in the market
The main cause of skin cancer is overexposure to sunlight, which is why sunscreens are crucial to the prevention of sun-induced skin damage. However, it is well known that many consumers apply less than the recommended amount of sunscreen, or even none at all.
We asked 5,600 consumers in eight different countries what they thought about sun protection and sunscreens and if/when/how they applied sun protection products.
The results were compared with earlier studies on use level, and in parallel the sensory profiles of several sunscreens have been analyzed. The aim was to understand potential barriers that lead to a lack of UV protection on the consumers side – and to develop solutions that are increasing the willingness of people to apply sunscreen as recommended.
Authors: Jürgen Vollhardt, Michele Marchini, Anne Jansen, Madina Sautova and Rotraut Schopp

Poster number: P-S2-331
Title: Prediction of in vivo SPF data: the role of the surface - UV filter interaction
Predicting SPF in vivo can be done by in vitro or in silico experiments. Key is that the sunscreen film on skin is not at all regular. Roughness has a strong influence on the performance. Prediction strategies often fail if this parameter is not adequately considered. We experimentally compared sunscreen film formation on skin and templates with confocal Raman microscopy and revealed significant differences that impact performance prediction. Taking those into account can make our models more accurate and more reliable.
Authors: Michael Edelmann1, Stefanie Hauser1, Patrick Schüepp1, Anne Janssen2, Karina Radomsky2, Jürgen Vollhardt2, and Christian Adlhart1

1 Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland;

2 DSM Nutritional Products Ltd, Personal Care, P.O. Box 2676, 4002 Basel, Switzerland