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DSM in Personal Care & Aroma Ingredients

The skin microbiome - the key to improving dry skin conditions?

SYN-UP® - fights against dry skin conditions

Common concerns about dry skin include a dull, rough, flacky complexion, red patches, and more visible facial lines. Earlier studies have shown that our peptide derivative SYN-UP® can improve skin barrier function by rebalancing urokinase and plasmin levels in the epidermis.  Now, a new clinical study shows that SYN-UP® also has excellent capacity to fight against dry skin conditions and, skin redness, due to its interaction on two common bacteria on the skin.

The role of Staphylococcus Epidermidis and Corynebacterium Kroppenstedtii in skin barrier health

Staphylococcus Epidermidis is a keystone bacterium for the skin. It has anti-inflammatory properties and most strains play a role in maintaining skin health (1) (2).

Corynebacterium Kroppenstedtii is also part of the normal skin microbiota, but increased levels have been associated with skin redness(3).

DSM’s novel, in vivo study reveals that SYN-UP® fights against dry skin conditions and skin redness by boosting levels of Staphylococcus Epidermidis and reducing Corynebacterium Kroppenstedtii levels. See graph:

Corynebacterium skin microbiome SYN-UP
staphylococcus epidermis skin microbiome SYN-UP

By influencing Staphylococcus Epidermidis and Corynebacterium Kroppenstedtii levels in the skin microbiome and rebalancing urokinase and plasmin symbiotically, SYN-UP® fights against dry skin conditions and redness. This means consumers can have confidence in achieving a stronger skin barrier and healthy-looking skin.

1) Journal of Dermatological Science 79 (2015) 119–126
2) Science 363 issue 6424 (2019), 227-228.
3) The cinco de mayo study 2018