Our unique peptide SYN-UP® has excellent capacity to improve the barrier functionality, by interacting with the skin microbiome, combats skin dryness, sensitivity and redness, and helps to smooth and firm the skin.

Beauty runs deep… our skin is a perfect ecosystem, multiple levels of cells and molecules all interconnected to build this great organ of the body. Over time external stressors such as UV irradiation, climate, pollution or chemicals can disbalance the skin. This process activates the production of Plasmin, triggering a series of skin damages and visible signs of aging. As a result skin becomes more fragile, prone to sensitization, loses its vitality and firmness, leaving the skin with an unhealthy appearance.

SYN-UP® is the peptide solution for multiple skin benefits. It improves the barrier functionality, by interacting with the skin microbiome, combats skin dryness, sensitivity and redness, and helps to smooth and firm the skin.

SYN-UP® is now allowed to be used in skincare formulations in the China market with its successful notification as a New Cosmetic Ingredient (NCI) in under the country’s new cosmetic legislation.

Mode of Action

SYN-UP® targets Plasmin 

SYN-UP® peptide is the key to unlock skin’s own true potential from within. Visualized with molecular modelling SYN-UP® peptide fits perfectly in the active site of Plasmin, like a key in a lock, with the objective of re-balancing Plasmin in the skin and reversing the negative impact. 

Product Features

  • INCI name (active): Amidinobenzyl Benzylsulfonyl D-Seryl Homophenylalaninamide Acetate
  • Sophisticated patented synthetic dipeptide derivative 


  • Promotes healthy-looking skin for longer by inhibiting Plasmin activities and by interacting with the skin microbiome**
  • Makes the skin more resilient against stress attacks day- by- day **
  • Real, significant prevention of dry skin conditions**
  • Reduces redness and unpleasant skin sensations**
  • Significant promotion of great looking skin**
  • Helps to smooth and firm the skin*

*In vitro **in vivo"

High Plasmin and Bacteria disbalance play a central role in unhealthy-looking skin

Plasmin is an enzyme responsible for protein activation and degradation and is widely present in the epidermis of the skin. High Plasmin activities:

Affect the Cornified Envelope, important for the protection and maintenance of the skin barrier.

Activate MMP 9 leading to increased levels of inflammatory cytokines and red skin conditions. Increased levels of MMP 9, which are also elevated in sun-exposed skin, mediate degradation of type IV Collagen, a major component in the Dermal Epidermal Junction.

Activate MMP 1 levels leading to the degradation of type I Collagen so the skin has less structural support2. When Collagen is compromised, skin loses elasticity & firmness.

Disbalanced bacteria: S. aureus affects skin barrier function via bacterial proteases, inflammation is triggered, and Plasmin is further activated leading to an even more vulnerable barrier1.​

1. Allergy Asthma Immunol Res. 2019 Sep;11(5): 593-603​
2. Experimental Dermatology 2018;27:520–525.

SYN-UP® unlock your skin's longevity

One biological target (Plasmin) to drive improvement across all skin layers

SYN-UP® promotes healthy-looking skin by inhibiting Plasmin and Urokinase* activities and balancing key bacteria S. Aureus* and S. Epidermidis**..

SYN-UP® reduces skin sensitivity and redness by modulation of MMP 9, CXCL5 and IL-8 activities*.

SYN-UP® increases skin barrier functionality by up-regulation of Transglutaminase 1 (TGase1)*.

SYN-UP® helps to smooth and firm the skin by preventing the degradation of type IV Collagen* and by stimulating type I Collagen*.

*in vitro ​ **in vivo

Approval On The Chinese Market

Apart from its unique mode of action, SYN-UP® is made even more competitive by its approval as a New Cosmetic Ingredient (NCI) in China under the country’s new cosmetic legislation. dsm-firmenich is the first company to receive NCI approval in the most stringent Category 3.

Years in the making, this achievement is augmented by the fact that between 2008 and 2020 only eight NCIs were ever approved.

China's New Cosmetics Regulation (CNCR) continues to employ a management system built on risk assessment. It implements a dual-track registration and notification mechanism for both new ingredients and the end-use product, aimed at improving cosmetics compliance throughout the lifecycle.

NCI’s approval only confirms that SYN-UP® meets the highest levels of quality and safety for an active peptide and means that the culmination of our innovation in peptide research, creation, and application is now made globally accessible to our customers and partners and it can be used freely in formulations all over the world.

Watch the video below to find out more.

Approval On The Chinese Market

SYN-UP® and sustainability

Request a Sample

As we only supply to businesses, we can only respond to business email addresses. Therefore, requests from personal email addresses (including @gmail.com, @hotmail.com or icloud.com) may not receive a response.

Please specify your job function

I  agree with DSM's User Terms and Conditions and acknowledge that DSM will process my personal data for the purposes described its Privacy Policy.

Stay up to date

Formulations Featured

Related Products



    ALPAFLOR® EDELWEISS CB is an organic bioactive that protects skin barrier, enhances skin resistance to external stress factors and provides an ultimate skin sensation. It is COSMOS and NATRUE organic certified and Fair for Life fair trade certified.



    The natural certified skincare ingredient STIMU-TEX® AS visibly reduces histamine-related symptoms like irritation and itching for a truly soothed and flawless looking skin.

  • ALL-Q Plus

    ALL-Q Plus

    ALL-Q Plus is a bioactive mix of coenzyme Q10 and vitamin E acetate in a cosmetic carrier oil. ALL-Q Plus is the ideal active ingredient for several key applications such as skin protection formulations (sun care, environmental stress) and others.



    ALPAFLOR® LINUM AO is a sustainable alpine plant extract of Linum alpinum. With its capacity to reduce the ICAM-1 expression induced by inflammatory cytokines, this natural, organic extract demonstrates calming properties for sensitive, irritated, and dry skin, proven in vitro. This bioactive is ECOCERT, COSMOS, and NATRUE organic certified, and Fair for Life fair trade certified.