Beauty Cream - Our Microbiome skin care formulation for dry skin
Our microbiome skin care formulation that brings power to your skin to fight dryness. It boosts staphylococcus epidermidis levels – the secret weapon for healthy looking skin.
A resilient skin barrier and equilibrium in the skin microbiome go hand in hand. Earlier studies have shown that our unique peptide cosmetic ingredient SYN-UP® can improve skin barrier function by rebalancing urokinase and plasmin levels in the epidermis. Now, a new clinical study shows that SYN-UP® also has excellent capacity to fight against dry skin conditions and, skin redness, due to its interaction on two common bacteria on the skin.
Sophisticated patented synthetic dipeptide derivative
Significant inhibition of urokinase activity by up to 97%
Significant inhibition of plasmin activity by up to 41%
Significant reduction of MMP9 by up to 60%
Strong reduction of CXCL5 and IL-8 – markers for skin sensitivity and inflammation
Inhibits Staphylococcus Aureus levels in vitro
Fights against dry skin conditions by boosting Staphylococcus
Epidermidis levels – the influential keystone for healthy skin
Improves skin barrier and reduces high Corynebacterium Kroppenstedtii levels – a novel target for the control of skin redness
It has been shown in vitro that SYN-UP® inhibits urokinase and plasmin and thus blocks downstream pathways, leading to high skin resilience and an improvement in dry skin conditions. DSM’s novel, in vivo study reveals that SYN-UP® fights against dry skin conditions and skin redness by boosting levels of Staphylococcus Epidermidis and reducing Corynebacterium Kroppenstedtii levels.
In skin conditions with reduced resilience such as dry skin, plasminogen is expressed in all epidermal cell layers and is activated by urokinase, causing release of plasmin. Plasmin and urokinase degrade and activate various proteins. This leads to degradation of corneodesmosomes, the intercellular adhesive structures that connect corneocytes, and to damage of extracellular structures, as well as to cells themselves, with increased desquamation of the skin. Plasmin activities also affect the cornified envelopes, which are important for the maintenance and integrity of the stratum corneum, and plasmin activates MMP 9, leading to increased levels of inflammatory cytokines. By influencing Staphylococcus Epidermidis and Corynebacterium Kroppenstedtii levels in the skin microbiome and rebalancing urokinase and plasmin symbiotically, SYN®-UP fights against dry skin conditions and redness. This means consumers can have confidence in achieving a stronger skin barrier and healthy-looking skin.