Boosting public health with vitamins for pharmaceutical applications

By: DSM Nutritional Products

Many people worldwide do not consume enough micronutrients to receive the health benefits available. While increased vitamin intake to meet recommendations can support the health of the general population, scientific research indicates higher doses of vitamins can also be used in the pharmaceutical industry to address specific health issues. 

Many people worldwide do not consume enough micronutrients to receive the health benefits available. Nutrition inadequacies and malnutrition are even more common in clinical conditions, for example, among vulnerable populations, such as elderly people, patients suffering from chronic conditions and patients recovering in hospitals1. This can lead to an increased risk of infection and, in turn, longer hospital stays. While increased vitamin intake to meet recommendations can support the health of the general population, scientific research indicates higher doses of vitamins can also be used in the pharmaceutical industry to address specific health issues.

Vitamins beyond essentiality

There is a growing bank of scientific data showing the benefits of vitamins can go beyond the essentiality offered by recommended daily intakes. Recent papers demonstrate that specific benefits may be achieved in particular at-risk groups by taking high dose vitamins. Vitamin E has also been shown to delay the onset of Alzheimer’s diseaseand reduce the risk of non-alcoholic fatty liver disease3.

Other health issues where a higher intake of nutrients beyond recommended nutritional requirements have been shown to provide therapeutic benefits in specific groups include cancer4,5, multiple sclerosisand diabetes7.

Pharmaceutical applications

Clinical data must be used in combination with a thorough understanding of drug-nutrient interactions to define the role of vitamins in the pharmaceutical industry. Grading of Recommendations Assessment, Development and Evaluation (GRADE) is one method for analyzing the evidence supporting the use of specific vitamins in pharmaceutical applications, which can be used as a reference for pharmaceutical and healthcare professionals.

The future of patient health

Understanding the role of vitamins beyond the nutritional range and their potential use in the pharmaceutical industry can lead to the creation of innovative products that will serve the interests of patient health worldwide.

For further information, read our whitepaper ‘Micronutrients for pharmaceutical applications’. Keep an eye out for our upcoming posts that will provide an in-depth view on emerging clinical evidence in this area.

Published on

23 August 2017

Share

4 min read

Sign up for our newsletter

Stay up-to-date on the latest science, events and market trends

Download our Pharma Solutions Catalogue

References

[1] M.J. Kaiser et al., ‘Frequency of malnutrition in older adults: a multinational perspective using the mini nutritional assessment’, J AM Geriatrics Soc, vol. 58, no. 9, 2010, p. 1734-8.

[2] M.W. Dysken et al., ‘Effect of vitamin E and memantine on functional decline in Alzheimer Disease’, JAMA, vol. 311, no. 1, 2014, p. 33-44.

[3] A. J. Sanyal et al., ‘Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis’, N Engl J Med, vol. 362, no. 18, 2010, p. 1675-85.

[4] S.J. Padayatty et al., ‘Vitamin C pharmacokinetics: implications for oral and intravenous use,’ Ann Intern Med, vol. 140, no. 7, 2004, p.533-7.

[5] H. Fritz et al., ‘Intravenous vitamin C and cancer: a systematic review,’ Integr Cancer Ther, vol. 13, no. 4, 2014, p. 280-300.

[6] A. Tourbah et al., ‘MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study’, Mult Scler. 2016, 22(13): 1719–1731.

[7] R. Valdés-Ramos et al., ‘Vitamins and type 2 diabetes mellitus’, Endocr Metab Immune Disord Drug Targets, 2015;15(1):54-63. 

Quick Links

Webshop

Request samples, place orders and view product documentation

Catalogue

Download the latest copy of our Solutions Catalogue

Contact Us

We’re more than a partner. We’re a competitive edge.

Whitepapers

The latest in vitamin and lipid research and industry developments

Webinars

Academic studies and the latest science in educational modules

Videos

Videos exploring the growing role of vitamin APIs and lipid API intermediates

This website does not constitute a recommendation or guidance for decisions concerning the purchase, use or application of products and does not relieve the user of the product of the obligation to undertake its own suitability, performance, quality testing or country specific regulatory approvals.  DSM Nutritional Products AG and its affiliated companies (hereinafter “DSM”) makes no representations or warranties, either express or implied, of merchantability, fitness for a particular purpose or of any other nature with respect to information or the products to which the information refers.  All trademarks, product names, symbols and graphics appearing on this website are the property of DSM.

Read more