Success stories in analytical science
Our customer success stories cover a wide range of industrial applications and processes – from materials and chemicals to biomedical, pharma and food.
Here is a small sample of challenges we have solved and the unique capabilities used to solve them. If you’d like to know more about the results achieved, please contact us today.
Materials & Chemicals
By taking a novel approaching to unpacking batch process data and applying novel multivariate analysis we helped plant engineers improve their monitoring of batch consistency and take action to avoid variations in future batches.
Detailed analysis was needed for our manufacturing customer covering outgassing and various other properties, from volatiles detection to decomposition and curing processes. By using TGA-FTIR advanced characterization methodologies we delivered it.
Our customer needed to find the kinetic parameters of the reaction of formic acid with hydrogen peroxide to form performic. We soon found that the quickest way to achieve it was by fitting the spectra time profiles at different temperatures.
Our customer was struggling to calibrate thermal properties of their material with its original properties. We used fast-scanning calorimetry techniques to help define the advanced characterization of the material, eg, crystallization processes.
Identifying (and eliminating) off odors during production is a common challenge for our customers in industries like food. Using molecular profiling techniques like GCxGC-TOFMS and relating them to odor evaluation, we are giving them valuable new insight.
The electronic components produced by our customer were suffering shorts, leading to a higher reject rate. By using elemental mapping - specifically, microphobe-EDXRF analysis – we identified the probable causes.
Our customer was finding that air-sensitive catalysts were deactivating. Our unique capabilities in Molecular Imaging provided valuable insight into the problem – and a subsequent improvement in performance using SEM-EDX imaging and mapping technologies.
Additive analysis is an excellent method for gaining an in-depth understanding of materials properties - but it can be time consuming. Using ASAP-MS (and even DOSY NMR qualitative screening methods) we achieved a breakthrough in effective additive analysis.
To help our customer better understand the distribution and organization of substances in (bio)materials, and how they caused defects, we used imaging and spectroscopic techniques including TOF-SIMS & MALDI MS, STEM-EDX and UV-VIS.
Our customer needed process optimization to help identify and reduce sample defects in polymer production. Through macromolecular characterization techniques including MALDI mass spectrometry we helped them achieve both.
A deep understanding of the primary, secondary and tertiary structure of our customers’ polymers was needed. We used NMR spectroscopy techniques to conduct a material analysis to provide this detailed structural information.
To help determine structural information and intermediate components needed for customer materials, we used online 13C-NMR spectroscopy to deliver a fast and accurate solution.
Manufacturers increasingly need chemical structure information of small molecules - like unknown impurities, volatiles, odor and unwanted residues. We delivered analysis of specific components in complex mixtures using a multi-disciplinary approach based on LC/GC-MS-NMR.
A medical device manufacturer was struggling with brittleness in their product after sterile irradiation, and needed to know if this was related to the molecular composition. By using SEC techniques with multi-detection we identified the cause.
A customer needed a better understanding of the degradation in its biomedical product (not least to meet regulatory requirements). We exposed the material to different stress factors (radiation, cell activity) and then used Mass Spectrometry to identify and quantify the degradation.
Coating constituents often contain polymeric structures. To help a customer understand them better we created a new LC method. As a result, more than ten different microstructures were detected and quantified.
A pharmaceutical customer needed more detailed knowledge on the relationship between randomness and ‘branching’ of polymers; and the release rates in controlled drug release devices. By using multi-detection SEC techniques, we were able to shed valuable light on the problem.