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DSM in Medical

Cardiovascular: Extending device performance

The challenge of treating cardiovascular disease requires specialized procedures and tools. Medical device manufacturers trust our innovative biomedical materials science to help make their devices both smaller and stronger to meet the growing needs of patients living longer lives.
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Helping medical devices work better

It’s estimated that the human heart beats about three billion times in the average lifetime. Given this demanding workload, it’s not surprising the heart can wear down. The prevalence of cardiovascular disease calls for surgical procedures that require medical devices strong and durable enough to withstand mechanical loadings, yet small and flexible enough to allow for endovascular implantation.

For example, valves and ventricular assist devices must be durable, stable and resistant to deterioration. Pacing and defibrillation leads need to be electrically insulated for patient safety and device effectiveness. The steering mechanism in PTCA and PTA catheters require durable, abrasion resistant cables which can follow the requirements for miniaturization while keeping the same strength. Plus, guidewires and catheters need to be strong and flexible with specialized lubricious coatings that make them easy to insert and maneuver inside the body.

DSM’s biomedical polyurethanes are clinically proven, with a twenty-year history of use in chronic implants. Our materials have been used in ventricular assist devices, pacemakers, defibrillators, vascular grafts, stents and central venous catheters. Our hydrophilic coatings are used on guidewires, introducer sheaths, shunts, stents and in various catheter applications. Dyneema Purity® fibers  are used in pushing and pulling cords in cardiovascular catheters to allow for miniaturization and can be used to reinforce these devices. In addition, Dyneema Purity® fibers can be used for cardiovascular sutures.

Bringing knowledge to life

With our proven expertise in Life Sciences and Materials Sciences, DSM supports medical device manufacturers by creating unique biomedical materials that have both the mechanical and biologic properties required to successfully address cardiovascular applications.

Our materials are used in drug delivery systems, such as a drug eluting stent. In this case, our technology enables the device manufacturer to control the release of the pharmaceutical directly into the vasculature of the patient’s heart and surrounding tissues. Our proprietary bioerodible amino-acid based drug delivery technology is capable of being custom tuned to permit drug release over times ranging days to months. DSM’s amino acid-based drug carrier delivers a range of active pharmaceutical agents including preventative blood clotting agents, immunosuppressants and a variety of other drugs – all this while degrading in controlled, biocompatible, natural and nontoxic. This technology is being evaluated for use in various injectable and implantable drug release solutions, including new therapies for treatment of cardiovascular diseases.

The Angio-Seal™ Vascular Closure device, developed by DSM, pioneered the concept of arterial puncture closure after cardiac catheterization procedures.  We have also established ourselves as an innovative leader in cardiovascular technology by developing a platform of endovascular products for treatment of thrombus and chronic total occlusion. Leveraging our fundamental biomaterials capabilities, today we have an extensive range of tissue regeneration products for a variety of hard and soft tissue applications. For patients, the benefits include safer, quicker and less invasive procedures, often resulting in shorter recovery time and longer-lasting results. In short, our cardiovascular expertise and products result in brighter lives and futures for more patients and their families.

Cardiac rhythm management

  • Cardiac assist devices such as artificial hearts and ventricular assist devices
  • Implantable cardiac defibrillators
  • Pacemakers and pacemaker leads

Interventional cardiology

  • Catheters: PTCA, PTA, guiding, central venous, intravascular imaging, pressure monitoring, ablation
  • Injectable and implantable drug release solutions
  • Guidewires
  • Transcatheter heart valves and their delivery systems
  • Introducer sheaths
  • Shunts
  • Stent (bare metal and drug eluting) and stent graft delivery systems
  • Sternum closure
  • Sutures
  • Vascular puncture closure devices

Collagen materials and technology - More>

  • Purified collagen
  • Solution and slurry processing
  • Collagen blending and compounding
  • Multiple configurations (sheets, putties, injectables, gels, three dimensional shapes, coatings, fibers, and powders)

Hydrophilic coatings

Polymers and metals processing technology - More>

  • Resorbable materials [Polylactide (PLA), Polylactide-co-glycolide (PLGA), Polycaprolactone (PCL), Polycarbonate (e.g. TMC)]
  • Non resorbable materials (PEEK, TPU)
  • Implant-grade metals ( titanium, stainless steel)

The Angio-Seal™Vascular Closure Device is exclusively licensed, manufactured, marketed and distributed by St. Jude Medical, Inc. Angio-Seal™ is a trademark of St. Jude Medical Inc.

QuickCat™ is a trademark of Spectranetics.