Unlocking the power of vitamin D for mobility health with ampli-D®

By:  Talking Nutrition Editors



  • Maintaining good mobility health is essential for an active lifestyle, independence and a rich quality of life.
  • Vitamin D plays a crucial role in mobility as it can support bone health and muscle function. However, achieving adequate vitamin D levels can be challenging due to limited sun exposure, a lack of natural food sources and slow-to-act supplements.
  • Calcifediol, such as dsm-firmenich’s ampli-D® solution, is a highly bioavailable form of vitamin D that offers a faster and more effective way to increase vitamin D levels compared to traditional vitamin D3 supplements. Read on to discover the science behind our calcifediol solution and its potential to support mobility.

Making mobility a health priority

Vitamin D, also known as the ‘sunshine’ vitamin, is a fat-soluble vitamin that is produced by humans, animals and fungi in the presence of the sun’s ultraviolet-B (UVB) rays. 1 It has most recently been in the spotlight for its role in immunity, 2 but it’s important to remember its benefits for mobility too.

Good mobility is essential for an active lifestyle, healthy independence and a rich quality of life. But several factors – including the natural aging process, poor nutrition, low physical activity, obesity, certain medications and chronic disease –can lead to weakness, reduced flexibility, slower movement and, ultimately, impaired mobility. 3 This is an increasing concern given we live in a world where obesity is extremely prevalent and the proportion of the elderly population is expected to double by 2050. 4, 5 As such, sustaining good mobility is a key health priority worldwide. In fact, 65% of consumers admitted they were worried about mobility, and senior adults (50-65 years of age) ranked mobility as their second biggest health concern globally. 6

Vitamin D: the key to good mobility

Vitamin D is well-recognized for its contribution to healthy mobility because of its important role in bone and muscle health. But it doesn’t work alone. Vitamin D helps the body absorb important minerals for bone strength, such as calcium and phosphorous. Studies have shown that vitamin D levels are associated with absorption of dietary calcium. 7, 8

Vitamin D deficiencies can lead to low levels of calcium, which – in turn – can trigger the release of calcium from bones for use in the bloodstream. the development of debilitating bone-related conditions like rickets in children or osteomalacia in adults. 9 In addition, inadequate vitamin D status increases the risk of falls, fractures and frailty which have a negative impact on quality of life and independence. 10, 11

The role of vitamin D in mobility extends beyond bones. Since muscles rely on calcium for nerve transmission and muscle contraction, maintaining adequate vitamin D levels is also essential for healthy muscle function. xi Not only this, but vitamin D can directly promote the synthesis of muscle fibers, enhancing fiber size and improving overall strength. xi

Understanding the difficulties associated with vitamin D intake

Achieving optimal levels of vitamin D, especially in the winter months when our skin is exposed to less sun, is challenging. To add to these difficulties, few foods naturally provide vitamin D. The best food sources of vitamin D are oily fish, egg yolks, red meat and liver. While maintaining a healthy and balanced diet that includes these foods is one way in which we can obtain vitamin D, it’s unlikely to supply us with enough. i

As a result, some products, like milks and cereals, have been fortified to increase vitamin D intake in the general population. Despite this, 88% of the world’s population has sub-optimal vitamin D levels. 12, 13 Dietary supplements are a convenient way in which people can boost their vitamin D intake, but it’s not aways a quick fix. Most supplements take months to build up to optimum status levels.

To expedite the increase of vitamin D concentrations, researchers have explored innovative ingredients – like calcifediol. When vitamin D3 supplements are metabolized in the liver, calcifediol is formed. 14 The increased bioavailability of calcifediol means it can elevate vitamin D levels faster – in just a matter of weeks xii, 15, 16 – to potentially unlock vitamin D benefits more rapidly than vitamin D3.

Power up your mobility solutions with ampli-D®

To drive innovation in this space, we developed a next generation calcifediol solution – ampli-D® . A clinical trial comprising 91 healthy older adults was conducted to compare the effectiveness of ampli-D® to standard vitamin D3 supplements. xv Results clearly indicated that ampli-D® was more easily used and absorbed by the body, achieving optimal levels of vitamin D up to three times faster than regular vitamin D3. xv But what about its role in mobility?

Available scientific research suggests the promising potential of calcifediol for mobility health. Two studies reported positive mobility outcomes for older adults consuming calcifediol. 17, 18, 19 Calcifediol supplementation increased muscle strength by 17%, gait speed by 18% and muscular function by almost three times compared to regular vitamin D3 in older women. Improved lower extremity muscle strength and function was further supported in a second study, with improved performance in Timed-Up-And-Go and Sit-To-Stand tests.

Because mobility is crucial for people of all ages to maintain an active lifestyle, the ability of ampli-D® to rapidly promote vitamin D status makes it a promising supplement for supporting bone and muscle health in kids and teens as well as adults and seniors. For manufacturers looking to innovate in the mobility health space and bring enhanced vitamin D solutions to consumers of all ages, ampli-D® is an effective and proven solution.

At dsm-firmenich, our dietary supplements team can help you create breakthrough products that are fueled by consumer insights, crafted with our expert services and brought to market faster with market-ready solutions such as ampli-D ® .

To learn more about the role of ampli-D ® in supporting mobility, download our brochure.


  1. The Nutrition Source, Harvard School of Public Health. Available at Vitamin D | The Nutrition Source | Harvard T.H. Chan School of Public Health 
  2. Aranow C. Vitamin D and the immune system. J Investig Med. 2011 Aug;59(6):881-6.
  3. Ebeling et al. Promoting mobility and healthy aging in men: a narrative review. Osteoporos Int., 30(10):1911-1922, 2019.
  4. Obesity and overweight (who.int)
  5. Ageing and health (who.int)
  6. dsm-firmenich Consumer Health Concerns Survey
  7. Holick. Vitamin D: the underappreciated D-lightful hormone that is important for skeletal and cellular health. Current Opinion in Endocrinology & Diabetes, (1):87-98, 2002.
  8. Wilson-Barnes SL, Lanham-New SA, Lambert H. Modifiable risk factors for bone health & fragility fractures. Best Pract Res Clin Rheumatol. 2022 Sep;36(3):101758
  9.  IOM (Institute of Medicine). Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: The National Academies Press, 2011
  10. Wicherts et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab., Jun;92(6):2058-65, 2007.
  11. Halfon et al. Vitamin D: a review on its effects on muscle strength, the risk of fall, and frailty. Biomed Res Int., 2015;953241, 2015
  12. Quesada-Gomez & Bouillon. Is calcifediol better than cholecalciferol for vitamin D supplementation? Osteoporos Int., 29:1697-1711, 2018.
  13. Hilger et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr, 111:23-45, 2014
  14. Brandi ML. Indications on the use of vitamin D and vitamin D metabolites in clinical phenotypes. Clin Cases Miner Bone Metab. 2010 Sep;7(3):243-50.
  15. Graeff-Armas et al. Supplemental 25-Hydroxycholecalciferol Is More Effective than Cholecalciferol in Raising Serum 25-Hydroxyvitamin D Concentrations in Older Adults. The Journal of Nutrition. 2020.
  16. Vaes, A.M.M.; Tieland, M.; de Regt, M.F.; Wittwer, J.; van Loon, L.J.C.; de Groot, L. Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults. Clin Nutr 2018.
  17. Corrado et al. Effects of different vitamin D supplementation schemes in post-menopausal women: A monocentric openlabel randomized study. Nutrients,(2):380, 2021.
  18.  Bischoff-Ferrari et al. Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity. Journal of Bone Mineral Research, 27(1):160-169, 2012.
  19. Meyer et al. Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial. Osteoporosis International, 26(1):373-381, 2015.

Published on

20 September 2023


4 min read

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