Future-proof your skin from the effects of daily stress

The patented innovative skincare ingredient that manages the undesired effects of a stressful lifestyle

Stress triggers cortisol release in the skin. Small amounts of cortisol help handle stress, but excessive amounts of cortisol can damage the skin, causing unwanted visible signs of ageing like lines and wrinkles, less elasticity, and reduced barrier functionality. With BEL-EVEN®, DSM has designed and patented a new cosmetic active ingredient that inhibits in vitro 11β-HSD1. BEL-EVEN® was specifically developed for skin care applications by using a rational design approach. It locally rebalances the negative, long-term effects of stress on skin and visibly reduces signs of a stressful lifestyle.

Product Features

  • INCI name (active): Biphenyl Azepanyl Methanone
  • Patented new to the world molecule with well-defined innovative mode of action
  • Rebalances cortisol level in skin by inhibiting the enzyme 11β-HSD1
  • Sustainable production process 
  • Does not contain intentionally added substances regulated/listed as preservative



  • Fights against stress-induced collagen loss and skin thinning
  • Leads to more supple-looking skin with improved skin elasticity
  • Significantly improves skin density and greater barrier integrity


Halal certified by Halal Food Council of Europe

Mode of Action

The human skin naturally responds to periods of stress with the formation of more cortisol through a particular enzyme; 11β-HSD1. This release of cortisol, the so-called stress hormone, is a normal and healthy adaptation reflex. However, cortisol can turn into an enemy of the skin if it remains in excess over a long period of time. 
BEL-EVEN® selectively inhibits the enzyme 11β-HSD1, particularly in keratinocytes, but also in fibroblasts, leading to rebalanced cortisol levels. This well-defined mechanism helps your skin to manage the undesired effects of a stressful lifestyle and skin elasticity, density and barrier functionality will improve.

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Related content

Missed our webinar?

Watch the presentation on BEL-EVEN® held at the Skin Protection Conference sponsored by cosmetic design!