An effective synthetic peptide ingredient found in the venom of the temple viper

SYN®-AKE is a small synthetic peptide that helps reduce the appearance of wrinkles and laughter lines – fast. As our skin gets older so the number of expression and laughter lines increases, along with crow’s feet and forehead wrinkles. SYN®-AKE enables the face to relax, reducing wrinkles but without losing the ability to help people express themselves. It’s fast acting, long lasting and fully reversible. New studies have now confirmed that when used earlier in time, SYN®-AKE helps delaying the appearance of wrinkles, with age-freezing effects.

Product Features

  • INCI name (active) : Glycerin, Aqua, Dipeptide Diaminobutyroyl Benzylamide Diacetate 
  • Synthetic tripeptide with mol weight below 500 Da 
  • Natural inspired mechanism 
  • Mimics Waglerin-1 functionality, a peptide found in the venom of the temple viper 
  • Safe for topical applications 
  • Preservative-free, glycerine-based aqueous solution 
  • Vegan-friendly


  • Age-killing effect particularly effective against expression lines
  • Visible deep wrinkle smoothing after only 4 weeks
  • Helps your face to relax without losing the ability to express yourself
  • When used earlier in time, SYN®️-AKE helps delaying the appearance of wrinkles, with age-freezing effect


See Regulatory Status China Statement
In 2006 SYN®-AKE won the well reputed and highly coveted Swiss Technology Award

Wrinkles on crow’s feet

Measurement of the smoothing (Ra) and anti-wrinkle effect (Rz and Rt) of SYN®-AKE (4%) measured on the crow’s feet after 28 days. 
With SYN®-AKE the depth of wrinkles is visibly reduced, and an overall smoother and more even skin surface appears.

Mode of Action

SYN®-AKE is based on a patented mechanism. It mimics the essential amino acid sequence of the Waglerin-1 functionality.
Its effect focuses on an immediate and lasting relaxation of mimic wrinkles. In vitro the peptide cosmetic ingredient is considered as an antagonist at the muscular nicotinic acetylcholine receptor (mnAChR). As the muscular nicotinic ACh receptors are reversibly blocked, the ion channel remains closed. There is no uptake of Na+ and the muscle cells stay relaxed. The transmission of nerve impulses to the muscles is inhibited and facial muscles are relaxed.

Timeless beauty- discover the powerful peptide designed for mothers and daughters

Recent DSM Trends’ Research has identified Medical Beauty as a fast-evolving consumer trend, referring to an increasing demand for highly effective skin care solutions, providing visible and immediate effects Our research also shows that, among newer generations, the fight against aging starts younger and younger. Millennials use anti-aging products from avg 26 y.o., more than 20 years earlier than previous generations, with a clear focus on preventing rather than reversing the signs of time.

And here- mothers can offer a window into daughters future:

New released “Mothers & Daughters” in vivo study!

Mimic wrinkles result from repetitive facial muscle contractions over time, that are linked to facial expressions. By associating the visualization of mothers & daughters, DSM shows this aging process: where daughters only show lines in expressive-face mode, mothers already show persistent wrinkles in relaxed-face mode. 

By helping to relax the face, SYN®️-AKE reduces the appearance of deep wrinkles and when used earlier in time can delay their progression, with an age-freezing effect.

The measurement of SYN®️-AKE (4%) effect was compared to a placebo. A cream was applied twice daily for 4 weeks. The study included total of 100 volunteers, 25 volunteers per group.

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