SYN®-AKE Safety Safety Data Sheet
SAFETY DATA SHEET for the peptide ingredient SYN®-AKE according to Regulation (EC) No. 1907/2006.
SYN®-AKE is a small synthetic peptide that helps reduce the appearance of wrinkles and laughter lines – fast. As our skin gets older so the number of expression and laughter lines increases, along with crow’s feet and forehead wrinkles. SYN®-AKE enables the face to relax, reducing wrinkles but without losing the ability to help people express themselves. It’s fast acting, long lasting and fully reversible. New studies have now confirmed that when used earlier in time, SYN®-AKE helps delaying the appearance of wrinkles, with age-freezing effects.
Measurement of the smoothing (Ra) and anti-wrinkle effect (Rz and Rt) of SYN®-AKE (4%) measured on the crow’s feet after 28 days.
With SYN®-AKE the depth of wrinkles is visibly reduced, and an overall smoother and more even skin surface appears.
SYN®-AKE is based on a patented mechanism. It mimics the essential amino acid sequence of the Waglerin-1 functionality.
Its effect focuses on an immediate and lasting relaxation of mimic wrinkles. In vitro the peptide cosmetic ingredient is considered as an antagonist at the muscular nicotinic acetylcholine receptor (mnAChR). As the muscular nicotinic ACh receptors are reversibly blocked, the ion channel remains closed. There is no uptake of Na+ and the muscle cells stay relaxed. The transmission of nerve impulses to the muscles is inhibited and facial muscles are relaxed.
Recent DSM Trends’ Research has identified Medical Beauty as a fast-evolving consumer trend, referring to an increasing demand for highly effective skin care solutions, providing visible and immediate effects Our research also shows that, among newer generations, the fight against aging starts younger and younger. Millennials use anti-aging products from avg 26 y.o., more than 20 years earlier than previous generations, with a clear focus on preventing rather than reversing the signs of time.
And here- mothers can offer a window into daughters future:
Mimic wrinkles result from repetitive facial muscle contractions over time, that are linked to facial expressions. By associating the visualization of mothers & daughters, DSM shows this aging process: where daughters only show lines in expressive-face mode, mothers already show persistent wrinkles in relaxed-face mode.
By helping to relax the face, SYN®️-AKE reduces the appearance of deep wrinkles and when used earlier in time can delay their progression, with an age-freezing effect.
The measurement of SYN®️-AKE (4%) effect was compared to a placebo. A cream was applied twice daily for 4 weeks. The study included total of 100 volunteers, 25 volunteers per group.