Extracellular Matrix technology, proven to preserve the biologic scaffold

We know that your product development journey for Extracellular Matrices (ECMs) starts with improved patient healing. Our ECM technology offers guided tissue regeneration to help you achieve this by mimicking natural tissue and enabling cellular integration – in everything from wound care and soft tissue reconstruction, to orthopedic and cardiovascular applications.

We work with partners worldwide across the continuum of healthcare to co-create ECM technology that supports patient healing – and bring progress to life  



10 years of commercial use.


Published in 40+ peer-reviewed journal articles globally.



30+ years of experience working with the world’s leading medical device and pharmaceutical companies.

Why choose our ECM solutions for your next development project?

Our biomimetic ECM scaffolds provide a naturally derived collagen structure, complemented by unique processing capabilities that maintain the natural properties of connective tissue (native growth factors, sugars, and proteins) - and help remove antigenic components.

Not only can we process a wide range of tissue sources and types for use in medical grade ECM scaffolds; our experts can combine our ECM materials with either our synthetic polymers or your own. In addition to all of this, we bring added peace of mind, through:

  • FDA Master File and support for global regulatory filings.
  • An established supply chain and robust quality system - with MDSAP certification.
  • Biomaterials compliant with applicable ISO and ASTM standards.

Portfolio Overview

Discover our ECM technology platforms

ECM sheets

Our ECM sheet materials are ideal for soft tissue reconstruction. Their unique mechanical qualities also make them ideal for multiple applications. 

  • Based on porcine dermis, peritoneum, and pericardium sources.
  • Available in multiple thicknesses. 
  • Provided in bulk decellularized sheets or as packaged and/or sterilized materials.

Custom ECM forms

We can easily modify our custom ECM forms to work smoothly with your existing processes and materials. 

  • Available as multi-material constructs, in alternative sizes, shapes, and thicknesses.
  • Supported by additional downstream capabilities, including size reduction (milling).

Custom development and manufacturing  

Our R&D experts can work with your tissues and processes through smooth production process transfers to co-create the ideal biologic scaffold.

  • This includes harvesting, cleaning, decellularization, disinfection, preservation, and sterilization of ECM materials.
  • Using other animal (non-human) tissue sources - including solid organs, tendons, bones, and nerves - for existing or new decellularization processing.

Application spotlight: Supporting biologic scaffolds

How do we create the ideal biologic scaffold material? The key is a gentle process that maintains the natural integrity of the natural micro and macro structure of the biologic tissue. At the same time, this process removes antigenic components like cellular remnants, DNA, and phospholipids – all while maintaining levels of other important ECM components.*

Today, our ECM materials are being used to treat patients worldwide in everything from wound care, to dental barrier membranes, orthopedic reinforcement, and soft tissue reconstruction.

We create sustainable healthcare solutions that deliver tangible and valuable sustainability benefits to our partners – with no compromises on safety or performance.

*The effects of these components have not been evaluated clinically.

Frequently Asked Questions

Here are common questions that our experts get asked. Do you have a different question? Contact us.

How is ECM different than collagen?

DSM’s extracellular matrices contain collagen, but due to their gentle and selective processing, they also contain native growth factors, elastin, and other extracellular components. Collagen is broken down and rebuilt to create customized forms; while ECM’s processing preserves the strength and features of the native tissue.

What form does ECM come in?

Our extracellular matrix is primarily available in sheet form; however, the process can be applied to many tissue types. This enables us to work closely with partners, providing customized solutions to meet their needs.

What class of clean room do you use to process your ECM?

DSM Biomedical produces ECM using current Good Manufacturing Practices (cGMP) in ISO Class 8 Clean Rooms. For more information, please see our Quality & Certifications.

Technical Resources

Looking for more information on how our ECM technology can help you tackle unmet needs?

ECM Datasheet

Medeor® Matrix Surgical Mesh

We understand that medical product development can be a long, winding - and occasionally bumpy road. Rest assured that at DSM Biomedical, we have the proven experience, capabilities, and knowledge to support you every step of the way. 

It starts with using a form-fit-function approach based on a comprehensive understanding of how the human body reacts to biomaterials following implantation. This in turn enables us to design materials that are compatible with the body’s physiology and help you develop finished products that can sustain, restore, and repair – all supported by applicable regulatory requirements. 


Our expert biomaterials team is here and ready to support you

Discover how we can partner with you to create innovative regenerative medicine and devices.

Need expert assistance?

Our ECM experts are here to help.                                                                                                                                                                                      

Explore our other Biomaterials 

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