Mycofix® Plus 5.Z with ZENzyme® is an innovative, all-in-one feed additive providing next-generation mycotoxin risk management for breeding animals and their offspring.
It uses three modes of action – adsorption, biotransformation and bioprotection – to deliver absolute protection against mycotoxins.
Faster and better zeralenone protection
ZENzyme® reduces zearalenone 1000 times faster to enhance reproductive performance.
Combats a broader spectrum of mycotoxins
Mycofix® Plus 5.Z deactivates zearalenone, fumonisins, trichothecenes, ochratoxin A, aflatoxins and ergot alkaloids.
Proven safety and efficacy
The only EU authorized and patented product ingredients proven to adsorb aflatoxins and biotransform trichothecenes and fumonisins into non-toxic metabolites.*
Mycofix® Plus 5.Z protects against a weakened immune system and lower performance caused by endotoxins and (emerging) mycotoxins. It provides Immune and liver support, strengthens the intestinal barrier and tight junctions in the presence of mycotoxins.
Verified economic advantage
Mycofix® Plus 5.Z protects your profits by preventing mycotoxin-induced reproductive, health and performance issues.
Mycofix® Plus 5.Z offers the fastest and most complete zearalenone mitigation thanks to ZENzyme®'s patented enzymatic biotransformation technology.
ZENzyme® is the first and only purified enzyme that degrades zearalenone (ZEN) fast, specifically and irreversibly into non-toxic and non-estrogenic metabolites.
Over 90% of all analyzed agricultural commodity samples contain one or more mycotoxins according to the latest DSM Mycotoxin Survey.
Mycotoxins impair the health status and performance of animals
Negative effects include impaired reproduction, digestive disorders, weakened immune function, carcinogenicity, hepatotoxicity, neurotoxicity and decreased performance—in addition to higher production costs and lower profits for producers.
In degradation experiments, ZENzyme® was scientifically proven to permanently degrade zearalenone.
The reaction of ZENzyme® is targeted, irreversible and immediate.
ZENzyme® added to ZEN-contaminaed feed detoxifies ZEN and prevents the negative effects in the animal.
ZENzyme® converts ZEN to hydrolyzed ZEN (HZEN) by hydrolyzing the ester bond of its lactone ring (Figure 1).
Figure 1. Enzymatic degradation of zearalenone by ZENzyme®.
The enzymatic reaction is specific and irreversible and the resulting metabolite hydrolyzed ZEN (HZEN) is non-toxic and non-estrogenic.
ZENzyme® completely hydrolyzes ZEN (orange line) in a very short period to the detoxified metabolite HZEN represented by the green line (Figure 2).
HZEN is not estrogenic as proven by the E-Screen assay using MCF-7 estrogen-sensitive breast cancer cells (Figure 3). Proliferation of these cells only occurs in the presence of estrogenic substances (e.g. ZEN). Cells are not stimulated to proliferate with HZEN underlining its lack of estrogenic activity.
Figure 2. Degradation of zearalenone (ZEN) by ZENzyme® to the detoxified form hydrolyzed ZEN (HZEN).
Figure 3. Proliferation of estrogen-sensitive MCF-7 cells when incubated with different concentrations of ZEN and its detoxified form hydrolyzed ZEN (HZEN), respectively.
A unique combination of patented targeted enzymes and biological components converts mycotoxins into non-toxic, environmentally-safe metabolites.
It's components are:
Mineral adsorbents selectively bind adsorbable mycotoxins such as aflatoxins and ergot alkaloids as well as endotoxins. Mycofix® contains EU authorized bentonite which binds more than 90% of aflatoxins, meeting the strict requirements set by the European Union Reference Laboratory (EURL).
The Biomin® Bioprotection Mix is an innovative mix of natural ingredients that protects against a weakened immune system and lower performance caused by endotoxins and (emerging) mycotoxins. It provides immune and liver support, strengthens the intestinal barrier and tight junctions in the presence of mycotoxins.
For more information about the application of Mycofix® please use the contact form to reach your local DSM representative.
Certain statements may not be applicable in all geographical regions. Product associated claims may differ based on government requirements.
Product availability may vary by country, please contact us for more information.
Mycofix® is not available in the US and Canada.