Mycofix® Plus 5.Z

DSM PERFORMANCE SOLUTIONS

Absolute protection against the broadest range of mycotoxins

Mycofix® Plus 5.Z with ZENzyme® is an innovative, all-in-one feed additive providing next-generation mycotoxin risk management for breeding animals and their offspring. ​

Looking for more information?

Reach out to us visit the Customer Portal if you are already a member.

How it Works

It uses three modes of action – adsorption, biotransformation and bioprotection – to deliver absolute protection against mycotoxins.​

Benefits of Mycofix® Plus 5.Z

  • Faster and better zeralenone protection
    ZENzyme® reduces zearalenone 1000 times faster to enhance reproductive performance.

  • Combats a broader spectrum of mycotoxins
    Mycofix® Plus 5.Z deactivates zearalenone, fumonisins, trichothecenes, ochratoxin A, aflatoxins and ergot alkaloids.

  • Proven safety and efficacy
    The only EU authorized and patented product ingredients proven to adsorb aflatoxins and biotransform trichothecenes and fumonisins into non-toxic metabolites.* 

  • Enhanced bioprotection
    Mycofix® Plus 5.Z protects against a weakened immune system and lower​ performance caused by endotoxins and (emerging) mycotoxins. It provides Immune and liver support, strengthens the intestinal barrier and tight junctions​ in the presence of mycotoxins.​

  • Verified economic advantage
    Mycofix® Plus 5.Z protects your profits by preventing mycotoxin-induced reproductive, health and performance issues.

Selected species

Mycofix® Plus 5.Z with ZENzyme® for Poultry

For poultry breeders and laying hens,
Mycofix® Plus 5.Z with ZENzyme® guards against mycotoxin-related issues and zearalenone-induced reproductive challenges. ​

Mycofix® Plus 5.Z with ZENzyme® protects: ​

  • Follicle count​
  • Number of fertile eggs​
  • Egg shell quality​
  • Male fertility​
  • Overall zootechnical performance​

*Mycofix® Plus 5.Z is not available in all markets/countries. To find out more, contact your DSM representative.

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Related Publications

MYCOTOXIN HUB

Latest Mycotoxin Updates

Read more about mycotoxins, get the latest mycotoxin survey reports and more.

Mycofix® Plus 5.Z with ZENzyme® for Pigs

For sows, gilts, piglets and boars,  Mycofix® Plus 5.Z with ZENzyme® guards against mycotoxin-related issues and zearalenone-induced reproductive challenges. ​

Mycofix® Plus 5.Z with ZENzyme® protects: ​

  • Number of piglets per sow​
  • Male fertility and semen quality​
  • Reproductive system integrity (e.g. prevention of prolapses)
  • Farrowing rate​
  • Overall zootechnical performance​

*Mycofix® Plus 5.Z is not available in all markets/countries. To find out more, contact your DSM representative.

×

Related Publications

MYCOTOXIN HUB

Latest Mycotoxin Updates

Read more about mycotoxins, get the latest mycotoxin survey reports and more.

Mycofix® Plus 5.Z with ZENzyme® for Ruminants

For dairy cows, calves and herd bulls,
Mycofix® Plus 5.Z with ZENzyme® guards against mycotoxin-related issues and zearalenone-induced reproductive challenges. ​

Mycofix® Plus 5.Z with ZENzyme® protects: ​

  • Hormonal balance for successful reproduction​
  • Pregnancy rate​
  • Embryo survival rate​
  • Calving intervals ​
  • Overall zootechnical performance​

*Mycofix® Plus 5.Z is not available in all markets/countries. To find out more, contact your DSM representative.

×

Related Publications

MYCOTOXIN HUB

Latest Mycotoxin Updates

Read more about mycotoxins, get the latest mycotoxin survey reports and more.

Mycofix® Plus 5.Z with ZENzyme® for Aquaculture

Zearalenone is known to have several negative consequences for fish and shrimp, including: ​

  • Reduction in broodstuck productivity​
  • Reduction in offspring survival​
  • Increased rate of mutations and malformations
  • Effects on gonads and roe​


For fish and shrimp, Mycofix® Plus 5.Z with ZENzyme® is designed to guard against  mycotoxin-related issues and zearalenone-induced reproductive challenges. ​

*Mycofix® Plus 5.Z is not available in all markets/countries. To find out more, contact your DSM representative.

Related Publications

MYCOTOXIN HUB

Latest Mycotoxin Updates

Read more about mycotoxins, get the latest mycotoxin survey reports and more.

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Mycofix® Plus 5.Z with ZENzyme® - The next-generation mycotoxin risk management solution

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Recording of the Virtual ZENzyme® Launch Event

What is behind Mycofix® Plus 5.Z

Mycofix® Plus 5.Z offers the fastest and most complete zearalenone mitigation thanks to ZENzyme®'s patented enzymatic biotransformation technology. ​

ZENzyme® is the first and only purified enzyme that degrades zearalenone (ZEN) fast, specifically and irreversibly into non-toxic and non-estrogenic metabolites.​

Mycotoxins - Harmful and Widespread

Over 90% of all analyzed agricultural commodity samples contain one or more mycotoxins according to the latest BIOMIN Mycotoxin Survey.

Mycotoxins impair the health status and performance of animals

Negative effects include impaired reproduction, digestive disorders, weakened immune function, carcinogenicity, hepatotoxicity, neurotoxicity and decreased performance—in addition to higher production costs and lower profits for producers.

Patented, Proven Technology

In degradation experiments, ZENzyme® was scientifically proven to permanently degrade zearalenone. ​

The reaction of ZENzyme® is targeted, irreversible and immediate. ​

ZENzyme® added to ZEN-contaminaed feed detoxifies ZEN and prevents the negative effects in the animal.
ZENzyme® converts ZEN to hydrolyzed ZEN (HZEN) by hydrolyzing the ester bond of its lactone ring (Figure 1).​

Want to learn more? Click the link below. 

Figure 1. Enzymatic degradation of zearalenone by ZENzyme®.

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The enzymatic reaction is specific and irreversible and the resulting metabolite hydrolyzed ZEN (HZEN) is non-toxic and non-estrogenic.​
 

ZENzyme® completely hydrolyzes ZEN (orange line) in a very short period to the detoxified metabolite HZEN represented by the green line (Figure 2).

HZEN is not estrogenic as proven by the E-Screen assay using MCF-7 estrogen-sensitive breast cancer cells (Figure 3). Proliferation of these cells only occurs in the presence of estrogenic substances (e.g. ZEN). Cells are not stimulated to proliferate with HZEN underlining its lack of estrogenic activity.

Figure 2. Degradation of zearalenone (ZEN) by ZENzyme® to the detoxified form hydrolyzed ZEN (HZEN).

Figure 3. Proliferation of estrogen-sensitive MCF-7 cells when incubated with different concentrations of ZEN and its detoxified form hydrolyzed ZEN (HZEN), respectively.


Proven Efficacy

  • Complete degradation of zearalenone (ZEN) in a fast, targeted and irreversible reaction.​
  • The resulting detoxified metabolite hydrolyzed zearalenone (HZEN) is non-estrogenic​.
  • ​Degradation of ZEN starts immediately after contact with saliva and there is a very high activity of the enzyme in gastric simulated buffer.​
  • Enzymatic activity as soon as sufficient moisture is available (20% moisture content). ​
  • ​Suitable as a feed additive for regular pelleting processes and in liquid feed.

Biotransformation

A unique combination of patented targeted enzymes and biological components converts mycotoxins into non-toxic, environmentally-safe metabolites.

It's components are:

  • ZENzyme®
  • FUMzyme®
  • Biomin® BBSH® 797
  • Biomin® MTV

ZENzyme®

ZENzyme® is the first and only purified enzyme that degrades zearalenone (ZEN) fast, specifically and irreversibly into non-toxic and non-estrogenic metabolites.​

FUMzyme®

The unique purified enzyme to degrade fumonisins (FUM) specifically and irreversibly into non-toxic metabolites.

Biomin® BBSH® 797

The microorganism that biotransforms trichothecenes (e.g. deoxynivalenol) into harmless metabolites.

Biomin® MTV

The patented yeast strain produces specific enzymes that degrade ochratoxin A into non-toxic substances.

Adsorption

Mineral adsorbents selectively bind adsorbable mycotoxins such as aflatoxins and ergot alkaloids as well as endotoxins. Mycofix® contains EU authorized bentonite which binds more than 90% of aflatoxins, meeting the strict requirements set by the European Union Reference Laboratory (EURL).

Bioprotection

The Biomin® Bioprotection Mix is an innovative mix of natural ingredients that protects against a weakened immune system and lower performance caused by endotoxins and (emerging) mycotoxins. It provides immune and liver support, strengthens the intestinal barrier and tight junctions in the presence of mycotoxins.

Application

For more information about the application of Mycofix® please use the contact form to reach your local DSM representative.

Certain statements may not be applicable in all geographical regions. Product associated claims may differ based on government requirements.
Product availability may vary by country, please contact us for more information.
Mycofix® is not available in the US and Canada.

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