Missed us live at IFSCC 2021? Download all our scientific findings here!

At IFSCC 2021, our scientists presented new innovations to address skin resilience, skin aging and hair loss and new findings on skin moisturization and the skin microbiome. If you couldn’t attend live, you can download the posters from their presentations and a recap of our award-winning scientist Rainer Voegeli’s keynote lecture below. 

Keynote Lecture - Moisturizing at a Molecular Level

Rainer Voegeli designs, conducts, and evaluates human studies to prove the efficacy of our skin care ingredients. At this year’s IFSCC Conference, we were proud to see him as a keynote speaker. In his lecture, he gave an overview of our 15 years of research on biological pathways for skin and explained why he believes that the basis for novel moisturizers lies in understanding effective maturation and desquamation of the stratum corneum. 

Poster - Boosting of retinol activity using novel LRAT-inhibitors

Imfeld, Dominik 1 *; Schütz, Rolf 1 ; Wikstroem, Peter 1 ; Rawlings, Anthony 2

1 Research and Development PCA, DSM Nutritional Products Ltd, Kaiseraugst, Switzerland; 2 AVR Consulting Limited, Northwhich, Cheshire, England UK

*corresponding author: Imfeld Dominik; (Dominik.Imfeld@dsm.com)

Retinol is well accepted as effective skin anti-aging ingredient. There is an ongoing desire in the cosmetic industry to boost the efficacy of exogenous or endogenous retinol to reduce concentrations in topical compositions. This poster explores how and why LRAT inhibition could offer a promising approach for further boosting the efficacy of retinol in skin care products to deliver superior anti-aging results. 

Poster - Development of a new, non-invasive method to detect the cortisol level in human skin

Imfeld, Dominik 1*; Kremp, Joerg 1 ; Gössl, Richard 2 ;

1 R&D Personal Care and Aroma, DSM Nutritional Products Ltd, Kaiseraugst, Switzerland; 2 R&D Solution Center, DSM Nutritional Products Ltd, Kaiseraugst, Switzerland

*corresponding author: Imfeld Dominik (Dominik.Imfeld@dsm.com)

Cortisol is recognized as key stress related hormonal marker but previous attempts to detect cortisol from skin have been of limited success.  This poster proposes a novel LC-MS/MS method for measuring cortisone and cortisol in the stratum corneum/ a new non-invasive method for detecting cortisol levels in human skin and assessing the effectiveness of a cortisol inhibitor treatment (BAM) which helped keep skin more resilient against external and mental stress factors.

Poster - Facial skin microbiota modulation by Epilobium fleischeri, a natural prebiotic plant extract

Sfriso, Riccardo1 *; Joshua, Claypoo 2; Roche, Magalie 3 ; Zhou, Zheng 4 ; Guo, Miao 4 ; Imfeld, Dominik 1

1 DSM Nutritional Products Ltd., Basel, Switzerland 2 DSM Nutritional Products, Nutrition Innovation Center, Lexington (MA), USA 3 Newtone Technologies, Lyon, France; 4 Mageline Biology Tech. Co. Ltd., Wuhan, China

*corresponding author: Sfriso Riccardo (Riccardo.Sfriso@dsm.com)

In the cosmetic industry, the cutaneous microbiota is increasingly considered fundamental to the maintenance of healthy skin. This poster explains how we assessed and visualized both bacterial composition at five different facial areas and the modulatory effects a prebiotic plant extract (Epilobium fleischeri) had on the microbiota in these areas.  

Poster - Biphenyl Azepanyl Methanone rescues glucocorticoid-induced growth arrest in human hair follicle dermal papilla cells

Remo Campiche 1*, Sevda Cordier-Dirikoc 2, Maxance Vandevyvere 2, Dominik Imfeld 1, Mathias Gempeler 1 , Eileen Jackson 1

1 DSM Nutritional Products, Personal Care & Aroma, Kaiseraugst, Switzerland; 2 Bioalternatives SAS, Gençay, France

*corresponding author: Remo Campiche (remo.campiche@dsm.com)

Stress-related hormones such as glucocorticoids have negative effects  on both skin and hair. We have already shown that the 11βHSD1 inhibitor Biphenyl Azepanyl Methanone (BAM) can protect skin from cortisol-induced collagen degradation. This paper describes our studies into its potential to work against stress-related hair loss by rescuing the inhibitory effect of cortisol on hair follicle dermal papilla cells.