Vitamin B12

The biotech pink vitamin for sensitive and stressed skin

A naturally derived colorant skin care ingredient that relieves sensitive skin with a healthy looking skin

Consumer demand for clean, safe, and eco-conscious beauty care ingredients is set to accelerate. This new grade of vitamin B12 is produced through non-GMO bacterial fermentation, has a natural origin index of 68.7% and is Halal approved and vegan compliant.  As a popular cosmetic ingredient, the vitamin ingredient B12 will certainly give your products an on-trend pink hue. Our new studies show, it could help relieve fatigued and irritated skin, protect the skin barrier, and promote a more vibrant looking complexion.

Product Features

  • INCI: Cyanocobalamin
  • Biotech naturally derived pink vitamin
  • Active on atopic dermatitis, reducing erythema and pruritus in vivo
  • Prevents inflammation ex vivo: significant and strong reduction of inflammasome and inflammatory cytokines such Il1-ß.
  • Epigenetic regulation of inflammasome: over-expression by 61% of miR-22-3p with vitamin B12 at 0.01% leads to a reduction of inflammasome ex vivo
  • Significantly reduction of Mast cell degranulation by 31%, drops the histamine release in vitro


  • Vitamin B12 relieves sensitive and stressed skin
  • Helps relieve skin conditions like itchy, irritated, inflamed, red and cracked skin
  • Help Prevent photo-damaged skin
  • Protects the skin barrier damage induced by inflammation
  • Plays an important part in speeding up cell recovery and regeneration
  • Skin looks more vibrant
  • Provides a nice and pleasant pink color of the cosmetic products
Halal certified by HFCE (Halal Food Council of Europe)
IECSC listed, IECIC listing

Mode of Action

UV, pollution, bacterial invasion or any oxidative stress induce the formation of the inflammasome, especially in keratinocyte. Its components are pro-Caspase-1, ASC and NLRP3 which is regulated by the epigenetic factor miRNA 22-3p. This inflammasome triggers and maintains the inflammatory response by cytokines production such as IL-1b. If it gets chronically activated, it causes skin irritation, skin tissue damage and premature aging.

Vitamin B12 maintains healthy skin microbiome

Vitamin B12 fosters the share of beneficial bacteria over non-beneficial skin bacteria. S. Aureus has been drastically reduced with Vitamin B12 while S. epidermidis remains at the same level.

A soothing formulation to tickle you pink

Frozen creams are quite re-gaining momentum, as keeping your creams chilled could help take away puffiness, boost circulation or helps relieve skin conditions like itchy, irritated, inflamed, red and cracked skin to the skin. But there are some concerns, that with cold temperatures skin care creams may lose their properties. DSM’s formulation expert Caroline Guillien will guide you through the process of formulating a cold cream and she will explain, on how the right ingredients will ensure that your skin care cream not lose its texture nor the properties when keeping it cold. Enjoy watching!


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