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Providing perspectives on recent research into vitamins and nutritionals


Beyond immunity: vitamin C may significantly reduce the risk of cardiovascular mortality

By Volker Elste, Senior Scientist at DSM Nutritional Products

  • New research shows a higher intake of vitamin C may reduce the risk of cardiovascular mortality by 70%
  • The study is the latest in a plethora of research supporting vitamin C’s role in supporting heart health
  • Supplementation can help individuals reach their desired vitamin C levels
  • A study by DSM has shown vitamin C to be the second most common supplement to be recommended by general practitioners (GPs) and pharmacists
  • In addition, other nutrients including omega-3 fatty acids EPA and DHA have been linked to improving cardiovascular health

Vitamin C has long been associated with immunity and, when faced with the common cold, a glass of orange juice is often the first thing people turn to for a boost. However, mounting evidence suggests that the health benefits of vitamin C may reach further than previously thought, particularly in supporting cardiovascular health. Notably, a study recently published in Nutrients has highlighted that an increased intake of the vitamin may significantly reduce the risk of cardiovascular mortality (CVM) and, in some models, the risk of cardiovascular disease (CVD), including myocardial infarction and stroke.[1]

As part of the Seguimiento Universidad de Navarra (SUN) project, data was collected from 13,421 individuals over the course of 11 years, with information gathered using questionnaires mailed to participants every two years. They were asked to report on how frequently they had consumed 136 different foods and beverages in the past 12 months, allowing researchers to understand not only the levels of vitamin C in their diets but other variables such as fiber and calorie intake. They were also required to provide medical details on any cardiovascular events they had experienced during this time. The analyzed data revealed that cardiovascular mortality was 70% less likely for those with a higher intake of vitamin C in their diet.

Unlocking the potential of vitamin C

As a powerful antioxidant, the potential role of vitamin C in reducing the risk of cardiovascular disease may be attributed to its ability to neutralize harmful free radicals, and in turn reduce oxidative stress. Research has also indicated vitamin C may support human health in a wider range of ways when the intake is high enough. For example, studies show that higher levels of vitamin C may help to lower blood pressure and can also help support the regeneration of other antioxidants, including vitamin E.[2],[3],[4],[5]

The recommended daily intake (RDI) of vitamin C varies from country to country, with the UK suggesting 40mg a day and the US recommending 75-90mg for healthy adults. [6],[7] However, many experts are in support of raising the global RDI to 200mg due to the wealth of evidence highlighting its benefits in higher doses. Emerging evidence on immune function, for example, suggest that daily intakes of 200 mg vitamin C might be advisable for the general adult population.[8] More on this topic will be discussed by leading experts at the symposium ‘Vitamin C – are current recommendations sufficient?’ during the 21st IUNS International Congress of Nutrition, taking place in Buenos Aires from October 15th- 20th.

Reaching new levels

Most commonly associated with oranges, foods such as broccoli, strawberry, kiwi, kale and bell peppers are all sources of vitamin C. However, achieving a higher dose of vitamin C through diet alone can be difficult, as the recommendation from WHO and FAO to have at least 5 daily servings of fruits and vegetables are frequently not reached.[9] While severe vitamin C deficiencies are not common nowadays, marginal deficiencies can be found in a large number of people, particularly in the US.[10] To effectively increase intake, vitamin C supplements can be used. A recent study by DSM set out to discover the opinions and awareness of healthcare practitioners on nutritional supplements and how this affects their interactions with patients. The results revealed that the second most common supplement to be recommended to patients by GPs and pharmacists is vitamin C.[11]

To find out more about how vitamin C, alongside other vitamins and omega-3s, may help to support heart health, read our whitepaper ‘The role of nutrients in supporting cardiovascular health’.


[1] N. Martin-Calvo and M.A Martinez-Gonzalez, ‘Vitamin C intake is inversely associated with cardiovascular mortality in a cohort of Spanish graduates: the SUN project.’, Nutrients, vol. 9, no.9, 2017, p.954.

[2] Moran et al, ‘Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects’, Am J Clin Nutr, vol.57, no. 2, 1993, p.213-217.

[3] Block et al, ‘Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women’, Nutr J, Vol. 7, No. 35, 2008.

[4] Myint et al, ‘Association between plasma vitamin C concentrations and blood pressure in the European prospective investigation into cancer-Norfolk population based study’, Hypertension, Vol. 58, No. 3, 2011, p. 372-379.

[5] U.S. Institute of Medicine, ‘Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids’, 2008. (Accessed 25 September 2017)

[6] NHS ‘Vitamin C overview’ (Accessed 25 September 2017).

[7] National Institutes of Health, ‘Vitamin C – fact sheet for consumers’, (Accessed 25 September 2017).

[8] V. Elste et al., ‘Emerging evidence on neutrophil motility supporting its usefulness to define vitamin C intake requirements.’, Nutrients, Vol 9, Issue 5, 2017,

[9] M.M. Murphy, ‘Global assessment of select phytonutrient intakes by level of fruit and vegetable consumption‘, B. J. Nutr., Vol. 112, 2014,  p. 1004–1018

[10] Troesch et al, ‘Dietary surveys indicate vitamin intakes below recommendations are common in representative Western countries.’, Br J Nutr, Vol. 108, No.4, 2012, p. 692-698.

[11] DSM, ‘Perception of nutritional supplements’, 2017.