Avian Gout/Kidney Failure

Selected Species

Signs of Avian Gout

Due to its complex etiology, avian gout is difficult to diagnose; however, the most common signs are dehydration, pale combs, depression and swelling and reddening of the feet which impair bird movement. In layers, where it is mainly observed, avian gout can lead to mortalities up to 50%, with 19-35 week-old hens most affected.

Causes

The causes of avian gout are varied (see table), ranging from management and/ or nutrition-related, to pathogens and/or the presence of mycotoxins in feed. In terms of nutrition, special attention must be paid to the calcium/phosphorus balance, sodium and vitamin D3. In general, any condition favoring an increase of uric acid in blood favors precipitation in tissue and, as a consequence, development of gout. Excess dietary calcium with low available phosphorus results in the precipitation of sodium-urate crystals and calcium pyrophosphate (pseudogout). In younger birds, gout due to sodium intoxication may be observed at sodium levels exceeding 0.4% in water and 0.8% in feed.

Likewise, high levels of vitamin D3 can increase calcium absorption from the intestine favoring the formation and deposition of urate crystals. Another nutrition-related cause is the protein level in feed which in excess of 30% causes uric acid production leading to excretory loads in kidneys. Concurrently, sulphates decrease calcium resorption causing excess calcium secretion through the urine. This favors gout, as well as any other factor contributing to urine alkalinity. Water deprivation falls in this category as it leads to increased concentrations of uric acid and other minerals in the blood and later on in the kidneys and urine.

Viruses such as infectious bursal disease (IBDV) and/or infectious bronchitis can enhance mortality in the presence of pre-existing kidney damage. In terms of mycotoxin contamination of poultry feeds, the nephrotoxic aflatoxins (Afla), ochratoxin A (OTA) and citrinin are of major concern. The impairment of the kidney function which results from the action of these mycotoxins reduces uric acid excretion and results in the accumulation of uric acid in the body.

Mycotoxins

Potential Cause

Check List

Corrective Action

Ochratoxin A (OTA), Citrinin, Aflatoxins (Afla)

Due to kidney damage, uric acid excretion is reduced resulting in the 
accumulation of uric acid in the body. At the farm, leg problems and increased water excretion may be observed.
• Positive for OTA, citrinin or Afla in raw materials (ELISA) or feed (HPLC).
• Raw materials originated from supplier/region with history of OTA contamination.
• Histopathology: Check other target organs of OTA and citrinin (e.g. kidneys).
• Overall decline in flock performance.
• Check average contamination levels.
• Add an effective mycotoxin deactivator in the feed.
• Avoid feed bins or feed/water lines to become contaminated by stale, wet or moldy feed.
• Prevent mold growth, purchase clean raw materials.

Nutrition

Potential Cause

Check List

Corrective Action


Protein
>30% of protein in feed causes uric acid production leading to excretory loads in kidneys. Concurrently sulphates decrease calcium resorption causing excessive calcium secretion through urine, which favors gout.
 
Protein levels in feeds • Correct protein levels in feeds.

Excess Ca in chick diets
Precipitates in the kidney and surrounding tissues.
 
Check feed formulation • Ensure correct level of Ca in diet.

High Na
Gout due to sodium intoxication  at >0.4% in water and >0.8% in feed.
 
Check water quality for salinity and feed formulation to maintain correct levels of salt. • Ensure water and feed are safe.
Excess Vitamin D
Increases Ca absorption from the blood.
Check premix formulation • Correct level of minerals and vitamin D3 in diets.
• Control total sodium chloride content in feed (<0.3% ).

Pathogens

Potential Cause

Check List

Corrective Action


Infectious Bronchitis (IB) especially nephropathgenic strains (QX)
IBD is very immunosuppressive and leads to kidney damage.
 
Maternal antibody titers are very low in day-old chicks. • Adapt vaccination program to the demands of the field situation in each particular area/epidemiology.
• Increase biosecurity level.

Infectious Bursal Disease (IBD)
IB causes respiratory disease and kidney damage in growers and oviduct infection in adults.
 
Laboratory tests to confirm the presence of the coronavirus in a swab or tissue sample. • Adapt vaccination program to the demands of the field situation in each particular area/epidemiology.

Others

Potential Cause

Check List

Corrective Action

Water deprivation

Water deprivation leads to concentration of uric acid and other minerals in the blood and later in the kidneys.
 
• Observe animal behavior to understand the cause of water deprivation.
• Transportation and vaccination procedures.
• Drinkers in terms of number, position and blockages that may be impeding animals to access them.
• Chemicals added into water (disinfectants, copper sulphate, etc.) may result in water refusal, dehydration and gout.

• Improve transportation condition of birds (access to water).
• Adjust number, position and access to drinkers.
• Avoid overcrowding.
• Correct blockages in nipples.

Solutions

  • Balancius®

    Together DSM and Novozymes have created Balancius® the first and only feed ingredient designed to unlock the hidden potential in gastrointestinal functionality.

  • PoultryStar®

    PoultryStar® is a well-defined, multi-species poultry probiotic plus prebiotic (synbiotic) that promotes a beneficial gut microflora and improves the results of broilers, layers and breeders.

  • CRINA®

    Our specific blends of essential oil components have shown to help deliver a better balance of gut microflora.

  • CYLACTIN®

    Increase the proportion of ‘good’ bacteria, and you have a better performing gut.

  • Biomin® CleanGrain Plus

    Biomin® CleanGrain Plus is a unique blend of organic acids and salts designed to protect against spoilage of grains and by-products caused by molds, yeast and bacteria.

  • Biotronic®

    The Biotronic® line of state-of-the-art enhanced acidifiers support modern farm animals against Gram-negative bacteria.

  • Digestarom® DC Power

    Digestarom® DC Power is a next generation phytogenic feed additive mixed into premixes, mineral feed or finished feed in order to support farm animal feed intake, support digestion and feed conversion. The Feed Converter.

  • Digestarom®

    Digestarom® line of phytogenics contain unique blends of herbs and spices, essential oils and other plant extracts to improve palatability and acceptance of feed, support digestion and overall performance of farm animals.

  • DHAgold™

    With DHAgold™ we bring you a sustainable source of DHA to enrich poultry, swine and aqua.

  • Symphiome™

    Symphiome™ is a complex glycan mixture technically defined as a Precision Biotic*. A first-of-its-kind microbiome metabolic modulator precisely designed to harness the power of the microbiome by modulating specific and highly conserved functional pathways to enhance the nutritional health and performance of the birds.

  • Mycotoxin Prediction

    The Mycotoxin Prediction Service delivers assessments of expected mycotoxin levels in the upcoming harvest of corn (maize) and wheat around the world.

  • Mycotoxin Contamination

    Our portfolio of tools helps to understand the potential risks of mycotoxins for animal species and location.

  • Mycofix®

    The Mycofix® portfolio of feed additives represents the most state-of-the-art solution for protecting animal health by deactivating mycotoxins that contaminate farm animal feed. Its safety and efficacy are proven by 7 EU authorizations for substances that deactivate mycotoxins.

  • FUMzyme® sol

    FUMzyme®, the only enzyme that effectively detoxifies fumonisins safely and irreversibly, is available for post-pellet and liquid application in animal feed. From the creators of Mycofix®. Naturally Ahead.

  • Mycofix® Plus 5.Z

    Absolute protection against the broadest range of mycotoxins. With ZENzyme® Faster and Better

  • BIOMIN Mycotoxin Survey

    The BIOMIN Mycotoxin Survey constitutes the longest running and most comprehensive data set on mycotoxin occurrence. The survey results provide insights on the incidence of the six major mycotoxins in the agricultural commodities used for livestock feed in order to identify the potential risk posed to livestock animal production.

  • Mycotoxin Detection

    We offer a range of analytical services to customers to assess the mycotoxin contamination of feed materials.

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